Objective: Hashimoto’s thyroiditis (HT) is an autoimmune disease that is common worldwide and may result in metabolic disorders. Adropin and phoenixin (PNX) are newly discovered peptides that play a role in the regulation of metabolic homeostasis in many tissues. The aim of the study was to investigate peripheral circulating levels of these two peptides in women with euthyroid HT and their relationship with the clinical parameters of these patients.

Material and Method: This case control study performed in 40 euthyroid women with HT and 38 age-matched healthy controls. Serum adropin and PNX-14 levels were determined by ELISA method.

Results: We found that there was no statistically significant difference between the patient and control groups regarding AST, ALT, fasting serum glucose, fasting insulin, triglyceride, HDL-C, HOMA-IR, free T3, free T4, TSH, adropin and PNX levels (p>0.05). LDL-C, total cholesterol, BMI values were higher than those of controls (p<0.05, p<0.005, p<0.001 respectively). AntiTPO, AntiTG levels were significantly higher than those of controls (p<0.001). There was no correlation between PNX-14 and adropin values and clinical parameters.

Conclusion: In this study, we found that there were no significant differences in PNX-14 and adropin concentrations between the euthyroid HT and control groups. Our study is important in that is the first study to examine adropin and pnx-14 levels in euthyroid HT.

Adropin Phoenixin-14 Hashimoto’s thyroiditis