RESEARCH ARTICLE
Nobel Med 2016; 12(2): 38-44

THE IMPACT OF hsCRP LEVELS ACROSS GLUCOSE TOLERANCE CATEGORIES: FROM NORMAL GLUCOSE TOLERANCE TO ESTABLISHED DIABETES

Yıldız Tütüncü, İlhan Satman, Selda Çelik, Bülent Canbaz, Fulya Türker, Nevin Dinççağ, Kubilay Karşıdağ, Ayşegül Telci, Sema Genç, Beyhan Ömer
ABSTRACT
Objective: To determine if there is an impact of high sensitive C-reactive protein (hsCRP) levels across different glucose tolerance categories.
Material and Method: Data derived from recently completed population-based survey, ‘The Prevalence of Diabetes, Obesity, Hypertension and Endocrine Disease in Turkey’ (TURDEP-II), which was performed in adult population (20+ years, n=26,499, 63% women).
Results: In women mean (±SEM) concentration of hsCRP was significantly higher than in men (3.95±0.05 vs. 3.53±0.09 mg/L, p<0.001). In general hsCRP (controlled for age, gender, and living environment) correlated positively with BMI, waist, fasting plasma glucose (FPG), 1-hPG, 2-hPG, insulin, HbA1c, HOMA-IR, eGFR, but inversely with HDL-c.
Univariate variance analysis (adjusted for age, gender, living environment, BMI, waist, BP, and lipids) revealed that hsCRP significantly differs across glucose tolerance status (p<0.001). Ad-hoc comparisons indicated that hsCRP (mg/L) in normal glucose tolerance (NGT: 3.49±0.13) group is significantly lower than isolated impaired fasting glucose (i-IFG: 4.13±0.25, p=0.023), combined glucose intolerance (CGI=IFG + impaired glucose tolerance [IGT]: 4.49±0.33, p=0.006), new diabetes mellitus (new-DM: 5.65±0.35, p<0.001) and known-DM (4.61±0.33, p=0.002) groups. However, hsCRP in new-DM group was significantly higher than all other categories (NGT: p<0.001, i-IFG: p<0.001, i-IGT: p=0.001, CGI: p=0.014, and known-DM: p=0.026).
Conclusion: According to the results from this large population-based survey, hsCRP levels showed a progressively increasing trend from NGT through new-DM categories. Any abnormality of glucose tolerance (either pre-DM or DM) is associated with subclinical inflammation. However, when the disease established, the influence of inflammatory process might become lesser than the earlier metabolic derangements.
Keywords
New diabetes Known diabetes Impaired fasting glucose Impaired glucose tolerance HsCRP levels

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  • Pubmed Style
    Yıldız Tütüncü, İlhan Satman, Selda Çelik, Bülent Canbaz, Fulya Türker, Nevin Dinççağ, Kubilay Karşıdağ, Ayşegül Telci, Sema Genç, Beyhan Ömer. [THE IMPACT OF hsCRP LEVELS ACROSS GLUCOSE TOLERANCE CATEGORIES: FROM NORMAL GLUCOSE TOLERANCE TO ESTABLISHED DIABETES]. Nobel Med 2016; 12(2): 38-44, English.
  • Web Style
    Yıldız Tütüncü, İlhan Satman, Selda Çelik, Bülent Canbaz, Fulya Türker, Nevin Dinççağ, Kubilay Karşıdağ, Ayşegül Telci, Sema Genç, Beyhan Ömer. [THE IMPACT OF hsCRP LEVELS ACROSS GLUCOSE TOLERANCE CATEGORIES: FROM NORMAL GLUCOSE TOLERANCE TO ESTABLISHED DIABETES]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English.
  • AMA (American Medical Association) Style
    Yıldız Tütüncü, İlhan Satman, Selda Çelik, Bülent Canbaz, Fulya Türker, Nevin Dinççağ, Kubilay Karşıdağ, Ayşegül Telci, Sema Genç, Beyhan Ömer. [THE IMPACT OF hsCRP LEVELS ACROSS GLUCOSE TOLERANCE CATEGORIES: FROM NORMAL GLUCOSE TOLERANCE TO ESTABLISHED DIABETES]. Nobel Med 2016; 12(2): 38-44, English.
  • Vancouver/ICMJE Style
    Yıldız Tütüncü, İlhan Satman, Selda Çelik, Bülent Canbaz, Fulya Türker, Nevin Dinççağ, Kubilay Karşıdağ, Ayşegül Telci, Sema Genç, Beyhan Ömer. [THE IMPACT OF hsCRP LEVELS ACROSS GLUCOSE TOLERANCE CATEGORIES: FROM NORMAL GLUCOSE TOLERANCE TO ESTABLISHED DIABETES]. Nobel Med (2016); 12(2): 38-44, [cited Mayıs 24, 2021], English.
  • Harvard Style
    Yıldız Tütüncü, İlhan Satman, Selda Çelik, Bülent Canbaz, Fulya Türker, Nevin Dinççağ, Kubilay Karşıdağ, Ayşegül Telci, Sema Genç, Beyhan Ömer. (2016) [THE IMPACT OF hsCRP LEVELS ACROSS GLUCOSE TOLERANCE CATEGORIES: FROM NORMAL GLUCOSE TOLERANCE TO ESTABLISHED DIABETES]. Nobel Med, 12(2): 38-44, English.