RESEARCH ARTICLE
Nobel Med 2016; 12(2): 13-19

MULTIPLE PRIMARY MALIGNANT NEOPLASMS FROM EASTERN BLACK SEA REGION OF TURKEY: SINGLE CENTER EXPERIENCE

Zümrüt Bahat, Mustafa Kandaz, Yahyahan Memiş, Emine Canyılmaz, Halil Kavgacı, Adnan Yöney
ABSTRACT
Objective: The incidence of multiple primary malignant neoplasms (MPMN) has been increasing worldwide. MPMN emerging after radiation therapy (RT) change in between the RT-centers and regions. In this study, we aimed to analyze the data on MPMN in a group of patients given RT in our center.
Material and Method: We analyzed all patients treated with RT in Karadeniz-Technical-University, Farabi-Hospital, Radiation-Oncology-Center between 1996-2012, retrospectively. MPMN diagnosis was made when each tumor presented a definite picture of malignancy. Demographical features, diagnoses of primary malignancies (PM) and secondary malignancies (SM), time to SM, stages of PM and SM, treatment type, presence of metastasis, and survival status were noted. Factors were analyzed for their relation to the survival.
Results: Among a total of 9440 patients, 102 (1.1%) were noted to develop MPMN with male: female ratio-of 4.2. Mean ages at-diagnoses of PM and SM were 58.8±13.9 years, and 64.1±12.8 years, respectively. Time to SM was 83.3±65.8 months. Larynx and lung were the two most frequent sites for primary and secondary tumors, respectively. There were considerable associations of “primary larynx/head&neck cancers with subsequent lung and urogenital cancers” and “primary urogenital cancers with subsequent urogenital and lung cancers”.
Conclusion: We conclude that patients >50 years of age, male patients and larynx cancer survivors need close surveillance for MPMN as lung cancer being the most common subsequent SM. Further analyses by individual centers are needed to construct an effective-surveillance for SM.
Keywords
Multiple primary malignant neoplasms Prevalence Radiotherapy Secondary Survival

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  • Pubmed Style
    Zümrüt Bahat, Mustafa Kandaz, Yahyahan Memiş, Emine Canyılmaz, Halil Kavgacı, Adnan Yöney. [MULTIPLE PRIMARY MALIGNANT NEOPLASMS FROM EASTERN BLACK SEA REGION OF TURKEY: SINGLE CENTER EXPERIENCE]. Nobel Med 2016; 12(2): 13-19, English.
  • Web Style
    Zümrüt Bahat, Mustafa Kandaz, Yahyahan Memiş, Emine Canyılmaz, Halil Kavgacı, Adnan Yöney. [MULTIPLE PRIMARY MALIGNANT NEOPLASMS FROM EASTERN BLACK SEA REGION OF TURKEY: SINGLE CENTER EXPERIENCE]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English.
  • AMA (American Medical Association) Style
    Zümrüt Bahat, Mustafa Kandaz, Yahyahan Memiş, Emine Canyılmaz, Halil Kavgacı, Adnan Yöney. [MULTIPLE PRIMARY MALIGNANT NEOPLASMS FROM EASTERN BLACK SEA REGION OF TURKEY: SINGLE CENTER EXPERIENCE]. Nobel Med 2016; 12(2): 13-19, English.
  • Vancouver/ICMJE Style
    Zümrüt Bahat, Mustafa Kandaz, Yahyahan Memiş, Emine Canyılmaz, Halil Kavgacı, Adnan Yöney. [MULTIPLE PRIMARY MALIGNANT NEOPLASMS FROM EASTERN BLACK SEA REGION OF TURKEY: SINGLE CENTER EXPERIENCE]. Nobel Med (2016); 12(2): 13-19, [cited Mayıs 24, 2021], English.
  • Harvard Style
    Zümrüt Bahat, Mustafa Kandaz, Yahyahan Memiş, Emine Canyılmaz, Halil Kavgacı, Adnan Yöney. (2016) [MULTIPLE PRIMARY MALIGNANT NEOPLASMS FROM EASTERN BLACK SEA REGION OF TURKEY: SINGLE CENTER EXPERIENCE]. Nobel Med, 12(2): 13-19, English.