RESEARCH ARTICLE
Nobel Med 2014; 10(1): 74-78

CYTOKINE GENE POLYMORPHISMS IN TURKISH PATIENTS WITH CHRONIC MYELOID LEUKAEMIA AND IN HEALTHY CONTROLS

Kürşat Özdilli, Sacide Pehlivan, Yeliz Duvarcı Öğret, Tuğçe Sever, Mustafa Pehlivan, Halim İşsever, Fatma Savran Oğuz
ABSTRACT
Objective: Cytokines that are released from activated lymphocytes, monocytes, and macrophages modify the intensity of immune inflammatory responses. Differences in cytokine production are due to sequence variants in cytokine genes. Cytokines are involved in all biological processes related to cell growth, cell differentiation, inflammation, and immunity. Early studies have demonstrated individual differences in cytokine production and an association between higher or lower cytokine production and disease. Chronic myelogenous leukaemia (CML) is a haematological malignancy that arises in haematopoietic stem cells with lymphoid and myeloid differentiation. Several studies have investigated the role of human leukocyte antigen (HLA) and cytokine gene polymorphisms in CML. The aim of this study was to analyse the role of cytokine polymorphisms in the aetiopathogenesis of CML. The susceptibility and protection of cytokine polymorphisms were evaluated.

Material and Method: A total of 300 adult healthy controls and 85 (70 adult and 15 paediatric) patients who were diagnosed with chronic-phase philadelphia chromosome (Ph)+ CML were included in this study. The typing was performed using the polymerase chain reaction-sequence specific primer (PCR-SSP) method. The allele and genotype frequencies of the following cytokine genes were determined: interleukin (IL)-6 (-174 G/C), IL-10 (-1082 G/A, -819 T/C, and -592 A/C), interferon-gamma (IFN-g) (+874 A/T), transforming growth factor-beta (TGF-ß) (C/T codon 10, C/G codon 25), and tumor necrosis factor- alpha (TNF-?) (-308 G/A).

Results: We found that the frequencies of the TNF-? GA and IL-6 GC genotypes were higher in the healthy controls, and the differences between the CML patients and the controls were statistically significant. The analysis of the allele frequencies did not reveal statistically significant differences between the controls and the CML patients at 8 loci.

Conclusion: The TNF-? GA and IL-6 GC genotypes may be protective alleles in CML patients.
Keywords
Cytokine gene polymorphism TNF-α IL-6 Chronic myeloid leukemia

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  • Pubmed Style
    Kürşat Özdilli, Sacide Pehlivan, Yeliz Duvarcı Öğret, Tuğçe Sever, Mustafa Pehlivan, Halim İşsever, Fatma Savran Oğuz. [CYTOKINE GENE POLYMORPHISMS IN TURKISH PATIENTS WITH CHRONIC MYELOID LEUKAEMIA AND IN HEALTHY CONTROLS]. Nobel Med 2014; 10(1): 74-78, English.
  • Web Style
    Kürşat Özdilli, Sacide Pehlivan, Yeliz Duvarcı Öğret, Tuğçe Sever, Mustafa Pehlivan, Halim İşsever, Fatma Savran Oğuz. [CYTOKINE GENE POLYMORPHISMS IN TURKISH PATIENTS WITH CHRONIC MYELOID LEUKAEMIA AND IN HEALTHY CONTROLS]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English.
  • AMA (American Medical Association) Style
    Kürşat Özdilli, Sacide Pehlivan, Yeliz Duvarcı Öğret, Tuğçe Sever, Mustafa Pehlivan, Halim İşsever, Fatma Savran Oğuz. [CYTOKINE GENE POLYMORPHISMS IN TURKISH PATIENTS WITH CHRONIC MYELOID LEUKAEMIA AND IN HEALTHY CONTROLS]. Nobel Med 2014; 10(1): 74-78, English.
  • Vancouver/ICMJE Style
    Kürşat Özdilli, Sacide Pehlivan, Yeliz Duvarcı Öğret, Tuğçe Sever, Mustafa Pehlivan, Halim İşsever, Fatma Savran Oğuz. [CYTOKINE GENE POLYMORPHISMS IN TURKISH PATIENTS WITH CHRONIC MYELOID LEUKAEMIA AND IN HEALTHY CONTROLS]. Nobel Med (2014); 10(1): 74-78, [cited Mayıs 24, 2021], English.
  • Harvard Style
    Kürşat Özdilli, Sacide Pehlivan, Yeliz Duvarcı Öğret, Tuğçe Sever, Mustafa Pehlivan, Halim İşsever, Fatma Savran Oğuz. (2014) [CYTOKINE GENE POLYMORPHISMS IN TURKISH PATIENTS WITH CHRONIC MYELOID LEUKAEMIA AND IN HEALTHY CONTROLS]. Nobel Med, 10(1): 74-78, English.