RESEARCH ARTICLE
Nobel Med 2023; 19(2): 105-113

THE LEVELS OF ADENOSINE TRIPHOSPHATE SYNTHASE 6, MANGANESE SUPEROXIDE DISMUTASE, NADPH-CYTOCHROME P450 REDUCTASE, LACTATE DEHYDROGENASE IN SEMINAL PLASMA OF OLIGOZOOSPERMIA AND NORMOZOOSPERMIA MEN

Esma Menevse, Duygu Dursunoglu, Emine Nedime Korucu, Nihal Çetin, Fatma Zehra Erbayram
ABSTRACT
Objective: In recent years, energy production and enzymes in mitochondrial pathways are an important in male fertilization.

Material and Method: For this purpose, we tried to determine the relationship between normozoospermia and oligozoospermia individuals according to levels of some mitochondrial enzymes. The seminal plasma levels of mitochondrial encoded adenosine triphosphate synthase 6 (mtATP6), manganese superoxide dismutase (Mn-SOD), NADPH-cytochrome P450 reductase (CPR), lactate dehydrogenase (LDH) were analyzed and assessed their correlations between data of spermogram. The study was composed of two groups consisting of normozoospermic and oligozoospermic volunteers.

Results: mtATP6 levels were significantly higher in normozoospermia (0.97±0.50 ng/mg protein, p=0.008) than oligozoospermia (0.64±0.32 ng/mg protein). LDH levels were higher in normozoospermia (0.25±0.074 U/ mg protein, p=0.007) than oligozoospermia (0.199±0.049 ng/mg protein). The groups did not differ in terms of MnSOD and CPR levels. mtATP6 levels were significantly correlated with sperm concentration, total number and total motility, immotility, total progressive motile sperm count (TPMSC) and long head anomaly. LDH levels were related with long head and short tail anomaly.

Conclusion: We observed some of the spermatogenetic anomalies are caused by defects in energy regulation. We did not find any evidence on MnSOD and CPR activity regarded as determinative parameters in response to increased oxidative stress in oligozoospermia.
Keywords
Infertility MnSOD LDH MtATP6 CPR

Authors Orcid Profiles

Esma Menevse
Duygu Dursunoglu
Emine Nedime Korucu
Nihal Çetin
Fatma Zehra Erbayram

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  • Pubmed Style
    Esma Menevse, Duygu Dursunoglu, Emine Nedime Korucu, Nihal Çetin, Fatma Zehra Erbayram. [THE LEVELS OF ADENOSINE TRIPHOSPHATE SYNTHASE 6, MANGANESE SUPEROXIDE DISMUTASE, NADPH-CYTOCHROME P450 REDUCTASE, LACTATE DEHYDROGENASE IN SEMINAL PLASMA OF OLIGOZOOSPERMIA AND NORMOZOOSPERMIA MEN]. Nobel Med 2023; 19(2): 105-113, English.
  • Web Style
    Esma Menevse, Duygu Dursunoglu, Emine Nedime Korucu, Nihal Çetin, Fatma Zehra Erbayram. [THE LEVELS OF ADENOSINE TRIPHOSPHATE SYNTHASE 6, MANGANESE SUPEROXIDE DISMUTASE, NADPH-CYTOCHROME P450 REDUCTASE, LACTATE DEHYDROGENASE IN SEMINAL PLASMA OF OLIGOZOOSPERMIA AND NORMOZOOSPERMIA MEN]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English.
  • AMA (American Medical Association) Style
    Esma Menevse, Duygu Dursunoglu, Emine Nedime Korucu, Nihal Çetin, Fatma Zehra Erbayram. [THE LEVELS OF ADENOSINE TRIPHOSPHATE SYNTHASE 6, MANGANESE SUPEROXIDE DISMUTASE, NADPH-CYTOCHROME P450 REDUCTASE, LACTATE DEHYDROGENASE IN SEMINAL PLASMA OF OLIGOZOOSPERMIA AND NORMOZOOSPERMIA MEN]. Nobel Med 2023; 19(2): 105-113, English.
  • Vancouver/ICMJE Style
    Esma Menevse, Duygu Dursunoglu, Emine Nedime Korucu, Nihal Çetin, Fatma Zehra Erbayram. [THE LEVELS OF ADENOSINE TRIPHOSPHATE SYNTHASE 6, MANGANESE SUPEROXIDE DISMUTASE, NADPH-CYTOCHROME P450 REDUCTASE, LACTATE DEHYDROGENASE IN SEMINAL PLASMA OF OLIGOZOOSPERMIA AND NORMOZOOSPERMIA MEN]. Nobel Med (2023); 19(2): 105-113, [cited Mayıs 24, 2021], English.
  • Harvard Style
    Esma Menevse, Duygu Dursunoglu, Emine Nedime Korucu, Nihal Çetin, Fatma Zehra Erbayram. (2023) [THE LEVELS OF ADENOSINE TRIPHOSPHATE SYNTHASE 6, MANGANESE SUPEROXIDE DISMUTASE, NADPH-CYTOCHROME P450 REDUCTASE, LACTATE DEHYDROGENASE IN SEMINAL PLASMA OF OLIGOZOOSPERMIA AND NORMOZOOSPERMIA MEN]. Nobel Med, 19(2): 105-113, English.