Aim: to study the correlation of the level of fibrinogen and the C-reactive protein (CRP) with other criteria of the metabolic syndrome.

Material and methods: The study was performed on 50 subjects who applied to our internal medicine out-patient clinic . Only patients without any known disease history but with at least three criteria of the metabolic syndrome on their routine lab tests were enrolled the study. All subjects were checked for their fasting blood glucose, tryglicerids, HDL-cholesterol, CRP and fibrinogen levels. The waist circumference of the subjects were measured. The subjects’ blood pressures were measured twice from their right arms after 10 minutes rest in supine position and the average value was taken.

Results: While the correlation between CRP levels and age was weak (r=0,40; p<0,01), there was a medium level correlation between CRP level and waist circumference (r=0,72; p<0,001). There was also a strong correlation between the fibrinogen level and fasting blood sugar level (r=0,76; p<0,001); and weak correalation between the fibrinogen level and tryglicerids level (r=0.40; p<0,01).

Conclusion: One of the pathophysiological mechanisms which explain the risk of atherosclerotic disease increasing with the metabolic syndrome, is the chronic subclinical inflammation. Measuring serum CRP and the fibrinogen levels – some of the inflammatory mediators – have been suggested as simple and reliable methods for the prediction and treatment of this disease.

Metabolic syndrome CRP Fibrinogen