RESEARCH ARTICLE
Nobel Med 2015; 11(3): 50-54

DETERMINATION OF TROPICAMIDE ABUSE IN HAIR WITH A VALIDATED GC-MS METHOD

Zeynep Türkmen, Selda Mercan, Sıtkı Bağdadi, Salih Cengiz
ABSTRACT
Objective: Tropicamide is an antimuscarinic drug used topically by clinicians prior to eye examination for its cycloplegic and mydriatic effects. It is included in the controlled drug-list since the second half of 2012 in Turkey due to abuse potential. There is no literature concerning the determination of tropicamide from hair sample. In this study, tropicamide determination method was validated partially by GC-MS and applied on an abuser's hair sample.
Material and Method: A validated method for tropicamide determination by GC-MS from hair was developed.
Results: Retention time of Tropicamide was found to be 12.79 min, linear range was between 15-1200 ng/mg with 0.998 correlation coeff.; accuracy, recovery and precision values were satisfactory. The method was successfully applied to a tropicamide abuser case and determined 63.61 ng/mg in hair.
Conclusion: This is the first report related to tropicamide abuse in hair in the literature. It was concluded that hair analysis is reliable technique to identify past substance abuse and it is necessary to reveal new strategies and notice the new trends of drug abuse.
Keywords
Tropicamide Cycloplegics Drug abuse Hair GC-MS

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  • Pubmed Style
    Zeynep Türkmen, Selda Mercan, Sıtkı Bağdadi, Salih Cengiz. [DETERMINATION OF TROPICAMIDE ABUSE IN HAIR WITH A VALIDATED GC-MS METHOD]. Nobel Med 2015; 11(3): 50-54, English.
  • Web Style
    Zeynep Türkmen, Selda Mercan, Sıtkı Bağdadi, Salih Cengiz. [DETERMINATION OF TROPICAMIDE ABUSE IN HAIR WITH A VALIDATED GC-MS METHOD]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English.
  • AMA (American Medical Association) Style
    Zeynep Türkmen, Selda Mercan, Sıtkı Bağdadi, Salih Cengiz. [DETERMINATION OF TROPICAMIDE ABUSE IN HAIR WITH A VALIDATED GC-MS METHOD]. Nobel Med 2015; 11(3): 50-54, English.
  • Vancouver/ICMJE Style
    Zeynep Türkmen, Selda Mercan, Sıtkı Bağdadi, Salih Cengiz. [DETERMINATION OF TROPICAMIDE ABUSE IN HAIR WITH A VALIDATED GC-MS METHOD]. Nobel Med (2015); 11(3): 50-54, [cited Mayıs 24, 2021], English.
  • Harvard Style
    Zeynep Türkmen, Selda Mercan, Sıtkı Bağdadi, Salih Cengiz. (2015) [DETERMINATION OF TROPICAMIDE ABUSE IN HAIR WITH A VALIDATED GC-MS METHOD]. Nobel Med, 11(3): 50-54, English.