INVESTIGATION OF POSSIBLE OXIDATIVE STRESS IN RATS DUE TO APPLICATION OF <sup>99m</sup>Tc DIMERCAPTOSUCCINIC ACID (DMSA)
Serdal Öğüt, Gökhan Cesur, Duygu Kumbul Doğuç, Mümin Polat, Mustafa YıldızABSTRACT
Materials and Methods: Serum total antioxidant capacity (TAC) and serum total oxidant capacity (TOC) were measured and then oxidative stress index (OSI) was calculated in rats (n=8) after giving technetium-99m pertechnetate (99mTc-DMSA) intravenously. In addition to these parameters in serum, the enzyme activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) and the levels of malondialdehyde (MDA) were measured in kidney tissues of rats. The same measurements both in serum and kidney tissues were also performed in non-administrated control rats (n=8).
Results: Based on the results obtained, oxidative stress index (OSI) and MDA levels were higher in the rats administrated 99mTc-DMSA than the rats in control group, whereas SOD, CAT and GSH-Px activities were lower in the rats treated with given 99mTc-DMSA.
Conclusions: These results indicate that 99mTc-DMSA administration leads to a negative effect on the antioxidant enzyme activities in rats.
CARNITINE AND ITS ROLE IN THE TREATMENT OF LIVER DISEASES
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09-13Mustafa Güler, Erhan Çapkın, Ömer Faruk Barçak, Murat Karkucak, Teoman Aydın, Ayşegül Küçükali Türkyılmaz, Adem Karaca, Ferhat Gökmen, Emine Poyraz
RESEARCH ARTICLE Nobel Med 2013; 9(3): 9-13THE EFFECT OF METFORMIN TREATMENT ON SERUM TOTAL VITAMIN B12, HOMOCYSTEINE AND TRANSCOBALAMIN LEVELS
14-21Abidin Şimşek, Ümit Aydoğan, Özlem Ciğerli, Halil Yaman, Kenan Sağlam
RESEARCH ARTICLE Nobel Med 2013; 9(3): 14-21EFFECTS OF ALL-TRANS RETINOIC ACID ON REDUCING HYPEROXIA-INDUCED OXIDATIVE STRESS IN MICE BRAIN
22-26Füsun Öztay, Bertan Boran Bayrak, Özgecan Kayalar, Refiye Yanardağ
RESEARCH ARTICLE Nobel Med 2013; 9(3): 22-26DETERMINATION OF SUBCLINICAL ATHEROSCLEROSIS IN OBSTRUCTIVE SLEEP APNEA SYNDROME PATIENTS WITHOUT TRADITIONAL RISK FACTORS FOR ATHEROSCLEROSIS
27-34Mustafa Serkan Karakaş, Refik Emre Altekin, Sinan Cemgil Özbek, Atakan Yanıkoğlu, Barış Akdemir, Arzu Er, Aykut Çilli, Ali Selim Yalçınkaya
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43-48Sabiha Şahin, Özkan Alataş
RESEARCH ARTICLE Nobel Med 2013; 9(3): 43-48THE SEROPREVALENCE OF HEPATITISA IN ADULTS IN İZMİR: PRIOR TO INTRODUCING VACCINE INTO ROUTINE VACCINATION PROGRAM
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RESEARCH ARTICLE Nobel Med 2013; 9(3): 49-53INVESTIGATION OF POSSIBLE OXIDATIVE STRESS IN RATS DUE TO APPLICATION OF <sup>99m</sup>Tc DIMERCAPTOSUCCINIC ACID (DMSA)
54-57Serdal Öğüt, Gökhan Cesur, Duygu Kumbul Doğuç, Mümin Polat, Mustafa Yıldız
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A PORTRAIT Nobel Med 2013; 9(3): 145-148INVESTIGATION OF POSSIBLE OXIDATIVE STRESS IN RATS DUE TO APPLICATION OF <sup>99m</sup>Tc DIMERCAPTOSUCCINIC ACID (DMSA)
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REPORT Nobel Med 2013; 9(3): 136-138-
Pubmed Style
Serdal Öğüt, Gökhan Cesur, Duygu Kumbul Doğuç, Mümin Polat, Mustafa Yıldız. [<sup>99m</sup>Tc DİMERKAPTOSÜKSİNİK ASİT (DMSA) UYGULAMASININ RATLARDA OLUŞTURABİLECEĞİ OLASI OKSİDATİF STRESİN ARAŞTIRILMASI]. Nobel Med 2013; 9(3): 54-57, Turkish. -
Web Style
Serdal Öğüt, Gökhan Cesur, Duygu Kumbul Doğuç, Mümin Polat, Mustafa Yıldız. [<sup>99m</sup>Tc DİMERKAPTOSÜKSİNİK ASİT (DMSA) UYGULAMASININ RATLARDA OLUŞTURABİLECEĞİ OLASI OKSİDATİF STRESİN ARAŞTIRILMASI]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish. -
AMA (American Medical Association) Style
Serdal Öğüt, Gökhan Cesur, Duygu Kumbul Doğuç, Mümin Polat, Mustafa Yıldız. [<sup>99m</sup>Tc DİMERKAPTOSÜKSİNİK ASİT (DMSA) UYGULAMASININ RATLARDA OLUŞTURABİLECEĞİ OLASI OKSİDATİF STRESİN ARAŞTIRILMASI]. Nobel Med 2013; 9(3): 54-57, Turkish. -
Vancouver/ICMJE Style
Serdal Öğüt, Gökhan Cesur, Duygu Kumbul Doğuç, Mümin Polat, Mustafa Yıldız. [<sup>99m</sup>Tc DİMERKAPTOSÜKSİNİK ASİT (DMSA) UYGULAMASININ RATLARDA OLUŞTURABİLECEĞİ OLASI OKSİDATİF STRESİN ARAŞTIRILMASI]. Nobel Med (2013); 9(3): 54-57, [cited Mayıs 24, 2021], Turkish. -
Harvard Style
Serdal Öğüt, Gökhan Cesur, Duygu Kumbul Doğuç, Mümin Polat, Mustafa Yıldız. (2013) [<sup>99m</sup>Tc DİMERKAPTOSÜKSİNİK ASİT (DMSA) UYGULAMASININ RATLARDA OLUŞTURABİLECEĞİ OLASI OKSİDATİF STRESİN ARAŞTIRILMASI]. Nobel Med, 9(3): 54-57, Turkish.