REVIEW
Nobel Med 2013; 9(3): 5-8

CARNITINE AND ITS ROLE IN THE TREATMENT OF LIVER DISEASES

Sebati Özdemir, Ahmet Aydın
ABSTRACT
Carnitine is an important essential cofactor in transfer of long chain fatty acids across the inner mitochondrial membrane. In humans, 75% of carnitine is obtained from the diet, and the remainder is endogenously synthesized by kidney, liver and brain. Plasma concentration of free carnitine is in dynamic balance with acylcarnitines with the acyl to free carnitine ration of ?0.4 being considered normal. Acetyl-L-carnitine is the principal acylcarnitine ester. Acetyl-L-carnitine participates in both anabolic and catabolic pathways in cellular metabolism. It is reported that especially treating minimal hepatic encephalopathy with carnitine exhibited recovery of symptoms and signs of the disease. In this paper, carnitine metabolism and its relations with liver diseases are reviewed.
Keywords
Carnitine Liver Metabolism Therapy

Article Details

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  • Pubmed Style
    Sebati Özdemir, Ahmet Aydın. [KARNİTİN VE KARACİĞER HASTALIKLARININ TEDAVİSİNDEKİ YERİ]. Nobel Med 2013; 9(3): 5-8, Turkish.
  • Web Style
    Sebati Özdemir, Ahmet Aydın. [KARNİTİN VE KARACİĞER HASTALIKLARININ TEDAVİSİNDEKİ YERİ]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish.
  • AMA (American Medical Association) Style
    Sebati Özdemir, Ahmet Aydın. [KARNİTİN VE KARACİĞER HASTALIKLARININ TEDAVİSİNDEKİ YERİ]. Nobel Med 2013; 9(3): 5-8, Turkish.
  • Vancouver/ICMJE Style
    Sebati Özdemir, Ahmet Aydın. [KARNİTİN VE KARACİĞER HASTALIKLARININ TEDAVİSİNDEKİ YERİ]. Nobel Med (2013); 9(3): 5-8, [cited Mayıs 24, 2021], Turkish.
  • Harvard Style
    Sebati Özdemir, Ahmet Aydın. (2013) [KARNİTİN VE KARACİĞER HASTALIKLARININ TEDAVİSİNDEKİ YERİ]. Nobel Med, 9(3): 5-8, Turkish.