RESEARCH ARTICLE
Nobel Med 2010; 6(3): 56-61

EVALUATION OF OXIDATIVE STRESS IN EXPERIMENTAL ACETAMINOPHEN INDUCED HEPATOTOXICITY: EFFECTS OF DARBEPOETIN ADMINISTRATION

Erman Aytaç, Pınar Seymen, Seha Saygılı, Habibe Genç, Hafize Uzun, Gülsen Özbay, Tuncay Altu, Hakkı Oktay Seymen, Muzaffer Sarıyar
ABSTRACT
Objective: Effects of darbepoetin alfa on acetaminophen induced hepatotoxicity have been investigated by evaluating some oxidant/antioxidant parameters and liver histology.

Material and Method: Fifty adult, male, Sprague-Dawley rats were randomly divided into five equal groups. Sham group (S); Acetaminophen (800 mg/kg, single dose, intraperitoneally) injected group (A); Darbepoetin alfa (10µg/kg, single dose, subcutaneously) administered at the same time with acetaminophen injection group (ASD); before acetaminophen injection darbepoetin administered group (DA); Darbepoetin administered after acetaminophen injection group (AD).

Results: Plasma AST and ALT levels of the A group, the ASD group, the DA group and the AD group were significantly higher than the S group (p<0.001). Plasma MDA levels of the ASD group, the DA group and the AD group were significantly higher than the A group (p<0.001). Plasma Cu-Zn SOD levels of the ASD (p<0.01), DA (p<0.01) and AD (p<0.001) groups was significantly lower than the A group.

Tissue Cu-Zn SOD levels of the ASD (p<0.01) group, the DA (p<0.001) group, and the AD (p<0.001) groups were significantly lower than the A group.

Conclusion: Darbepoetin alfa administration could not support the antioxidant parameters in acetaminophen induced hepatotoxicity. Timing of darbepoetin alfa administration for liver toxicity could be an important factor for the efficacy of the treatment.

Keywords
Acetaminophen; hepatotoxicity; darbepoetin alfa; oxidative stress

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  • Pubmed Style
    Erman Aytaç, Pınar Seymen, Seha Saygılı, Habibe Genç, Hafize Uzun, Gülsen Özbay, Tuncay Altu, Hakkı Oktay Seymen, Muzaffer Sarıyar . [EVALUATION OF OXIDATIVE STRESS IN EXPERIMENTAL ACETAMINOPHEN INDUCED HEPATOTOXICITY: EFFECTS OF DARBEPOETIN ADMINISTRATION ]. Nobel Med 2010; 6(3): 56-61, English.
  • Web Style
    Erman Aytaç, Pınar Seymen, Seha Saygılı, Habibe Genç, Hafize Uzun, Gülsen Özbay, Tuncay Altu, Hakkı Oktay Seymen, Muzaffer Sarıyar . [EVALUATION OF OXIDATIVE STRESS IN EXPERIMENTAL ACETAMINOPHEN INDUCED HEPATOTOXICITY: EFFECTS OF DARBEPOETIN ADMINISTRATION ]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English.
  • AMA (American Medical Association) Style
    Erman Aytaç, Pınar Seymen, Seha Saygılı, Habibe Genç, Hafize Uzun, Gülsen Özbay, Tuncay Altu, Hakkı Oktay Seymen, Muzaffer Sarıyar . [EVALUATION OF OXIDATIVE STRESS IN EXPERIMENTAL ACETAMINOPHEN INDUCED HEPATOTOXICITY: EFFECTS OF DARBEPOETIN ADMINISTRATION ]. Nobel Med 2010; 6(3): 56-61, English.
  • Vancouver/ICMJE Style
    Erman Aytaç, Pınar Seymen, Seha Saygılı, Habibe Genç, Hafize Uzun, Gülsen Özbay, Tuncay Altu, Hakkı Oktay Seymen, Muzaffer Sarıyar . [EVALUATION OF OXIDATIVE STRESS IN EXPERIMENTAL ACETAMINOPHEN INDUCED HEPATOTOXICITY: EFFECTS OF DARBEPOETIN ADMINISTRATION ]. Nobel Med (2010); 6(3): 56-61, [cited Mayıs 24, 2021], English.
  • Harvard Style
    Erman Aytaç, Pınar Seymen, Seha Saygılı, Habibe Genç, Hafize Uzun, Gülsen Özbay, Tuncay Altu, Hakkı Oktay Seymen, Muzaffer Sarıyar . (2010) [EVALUATION OF OXIDATIVE STRESS IN EXPERIMENTAL ACETAMINOPHEN INDUCED HEPATOTOXICITY: EFFECTS OF DARBEPOETIN ADMINISTRATION ]. Nobel Med, 6(3): 56-61, English.