Objective: The aim of the study was to investigate the prevalance of primary headache and clinical evaluation of primary headaches according to the International Headache Society criteria in patients with multiple sclerosis. The relationship between primary headache and multiple sclerosis subtypes, locations of plaques on magnetic resonance of these patients were also investigated.
Material and Method: A total of 31 patients with clinically definite MS according to the McDonald’s criteria, 22 females and 9 men, were included in the study. The study conducted in two phases; face-to-face interview phase and evaluation of magnetic resonance imaging phase.
Results: The prevalance of all headaches was 71.0 % in 31 patients . Migraine without aura was found in 22.6%, migraine with aura in 19.4% and tension type headache in 29%. Primary headaches were found to be most common in relapsing-remitting MS. Lesions of red nucleus (RN), substantia nigra(SN), periaquaductal gray matter(PGM), dorsolateral pontine nucleus (DPN) were found in all patients, with frequency from 22.6% to 48.4%. While all patients with migraine had supratentoriel lesion, neither of the patients had infratentoriel lesion alone.
Conclusion: The findings suggest that primary headaches are common in patients with multiple sclerosis. Demyelinating lesions in RN,SN,PGM, DPN might be responsible from the presence of primary headaches in patients with MS. But for understanding the mechanisms underlying this association, further studies are needed.

Migraine; Multiple Sclerosis; headache; prevalance; magnetic resonance imaging