RESEARCH ARTICLE
Nobel Med 2009; 5(3): 58-64
AORTIC ELASTIC PROPERTIES, CAROTID INTIMA-MEDIA THICKNESS AND CORONARY FLOW RESERVE IN PATIENTS WITH PERIPHERAL ARTERY DISEASE
Hüseyin Oflaz, Ali Elitok, Arif Çimen, Burak Pamukçu, Mustafa Tükenmez, İmran Onur, Ebru Gölcük, Erdem Kaşıkçıoğlu, Ramazan Kurt, Mustafa Demirtürk, Murat AksoyABSTRACT
Material and Methods: Twenty-seven patients with PAD (ankle-brachial index (ABI) <0.9) and 26 healthy subjects without claudication (ABI>1) were studied. Coronary diastolic peak flow velocities were measured baseline and after dipyridamole infusion. The ratio of hyperemic to baseline diastolic peak velocities (CFR), aortic strain and distensibility were calculated. The intima media tickness (IMT) of the carotid arteries were also measured.
Results: Demographic parameters and risk factors of coronary artery disease were similar between the patient and control groups. Baseline diastolic peak and mean flow velocities were similar between the patients with PAD and healthy control subjects (p=0.56 and p=0.69 respectively). Hyperemic diastolic peak and mean flow velocities were significantly lower in the patient group compared to those in controls (45,64±14,21 cm/s vs 73,08±29,61 cm/s p<0.01 and 35,68±10,83 cm/s vs 54,31±22,28 cm/s p<0.01). CFR was 1,49±0,36 and 2,51±0,74 in patients and healthy control subjects respectively (p<0.01). The IMT was significantly increased in patients with PAD (p<0.01). Both, aortic strain and distensibility were impaired in patients with PAD (p<0.01).
Conclusion: The present study showed that CFR, which establishes coronary microvascular and endothelial functions non-invasively, is significantly impaired in patients with PAD. The impaired CFR, increased carotid IMT, decreased aortic strain and distensibility, as early atherosclerotic changes, may have value in the prediction of coronary artery disease in patients at risk for coronary atherosclerosis.
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Pubmed Style
Hüseyin Oflaz, Ali Elitok, Arif Çimen, Burak Pamukçu, Mustafa Tükenmez, İmran Onur, Ebru Gölcük, Erdem Kaşıkçıoğlu, Ramazan Kurt, Mustafa Demirtürk, Murat Aksoy. [AORTIC ELASTIC PROPERTIES, CAROTID INTIMA-MEDIA THICKNESS AND CORONARY FLOW RESERVE IN PATIENTS WITH PERIPHERAL ARTERY DISEASE]. Nobel Med 2009; 5(3): 58-64, English. -
Web Style
Hüseyin Oflaz, Ali Elitok, Arif Çimen, Burak Pamukçu, Mustafa Tükenmez, İmran Onur, Ebru Gölcük, Erdem Kaşıkçıoğlu, Ramazan Kurt, Mustafa Demirtürk, Murat Aksoy. [AORTIC ELASTIC PROPERTIES, CAROTID INTIMA-MEDIA THICKNESS AND CORONARY FLOW RESERVE IN PATIENTS WITH PERIPHERAL ARTERY DISEASE]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English. -
AMA (American Medical Association) Style
Hüseyin Oflaz, Ali Elitok, Arif Çimen, Burak Pamukçu, Mustafa Tükenmez, İmran Onur, Ebru Gölcük, Erdem Kaşıkçıoğlu, Ramazan Kurt, Mustafa Demirtürk, Murat Aksoy. [AORTIC ELASTIC PROPERTIES, CAROTID INTIMA-MEDIA THICKNESS AND CORONARY FLOW RESERVE IN PATIENTS WITH PERIPHERAL ARTERY DISEASE]. Nobel Med 2009; 5(3): 58-64, English. -
Vancouver/ICMJE Style
Hüseyin Oflaz, Ali Elitok, Arif Çimen, Burak Pamukçu, Mustafa Tükenmez, İmran Onur, Ebru Gölcük, Erdem Kaşıkçıoğlu, Ramazan Kurt, Mustafa Demirtürk, Murat Aksoy. [AORTIC ELASTIC PROPERTIES, CAROTID INTIMA-MEDIA THICKNESS AND CORONARY FLOW RESERVE IN PATIENTS WITH PERIPHERAL ARTERY DISEASE]. Nobel Med (2009); 5(3): 58-64, [cited Mayıs 24, 2021], English. -
Harvard Style
Hüseyin Oflaz, Ali Elitok, Arif Çimen, Burak Pamukçu, Mustafa Tükenmez, İmran Onur, Ebru Gölcük, Erdem Kaşıkçıoğlu, Ramazan Kurt, Mustafa Demirtürk, Murat Aksoy. (2009) [AORTIC ELASTIC PROPERTIES, CAROTID INTIMA-MEDIA THICKNESS AND CORONARY FLOW RESERVE IN PATIENTS WITH PERIPHERAL ARTERY DISEASE]. Nobel Med, 5(3): 58-64, English.