REPORT
Nobel Med 2007; 3(3): 31-34

TOXICITY RESULTING FROM METHOTREXATE TAKEN MISTAKENLY FOR A LONG TIME INSTEAD OF L-THYROXINE: DO WE INFORM OUR PATIENTS ABOUT THEIR TREATMENT SUFFICIENTLY?

Şule Namlı, Abdullah Özkök, Yaşar Çolak, Nilgün Erten, M. Akif Karan, Cemil Taşçıoğlu, Abdülkadir Kaysı
ABSTRACT
Methotrexate is a drug commonly used in the treatment of acute lymphoblastic leukemia, lymphoma, choriocarcinoma, and some solid tumors as a chemotherapeutic agent and also used frequently in the treatment of chronic non-neoplastic diseases such as rheumatoid arthritis, psoriasis. During methotrexate administration, serious adverse effects may develop at any stage of the treatment such as nausea, vomitting, oral ulceration, anorexia caused by gastrointestinal system toxicity; increased hepatic enzyme levels because of hepatotoxicity, leukocytopenia and thrombocytopenia due to bone marrow suppression. In this article we present a case of a patient who had taken methotrexate mistakenly for 6 months instead of thyroid hormone replacement treatment. He was admitted to the hospital with leukopenia and oral ulcers and thereafter he developed febrile neutropenia. We emphasize that the physicians must obtain a detailed history from their patients, inform their patients sufficiently and be more careful when they follow up their treatment and its effectiveness.
Keywords
Methotrexate Oral ulcers Leukopenia Medication errors

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  • Pubmed Style
    Şule Namlı, Abdullah Özkök, Yaşar Çolak, Nilgün Erten, M. Akif Karan, Cemil Taşçıoğlu, Abdülkadir Kaysı. [L-TİROKSİN YERİNE YANLIŞLIKLA UZUN SÜRE METOTREKSAT KULLANIMINA BAĞLI TOKSİSİTE: HASTALARI TEDAVİLERİ KONUSUNDA YETERİNCE BİLGİLENDİRİYOR MUYUZ?]. Nobel Med 2007; 3(3): 31-34, Turkish.
  • Web Style
    Şule Namlı, Abdullah Özkök, Yaşar Çolak, Nilgün Erten, M. Akif Karan, Cemil Taşçıoğlu, Abdülkadir Kaysı. [L-TİROKSİN YERİNE YANLIŞLIKLA UZUN SÜRE METOTREKSAT KULLANIMINA BAĞLI TOKSİSİTE: HASTALARI TEDAVİLERİ KONUSUNDA YETERİNCE BİLGİLENDİRİYOR MUYUZ?]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish.
  • AMA (American Medical Association) Style
    Şule Namlı, Abdullah Özkök, Yaşar Çolak, Nilgün Erten, M. Akif Karan, Cemil Taşçıoğlu, Abdülkadir Kaysı. [L-TİROKSİN YERİNE YANLIŞLIKLA UZUN SÜRE METOTREKSAT KULLANIMINA BAĞLI TOKSİSİTE: HASTALARI TEDAVİLERİ KONUSUNDA YETERİNCE BİLGİLENDİRİYOR MUYUZ?]. Nobel Med 2007; 3(3): 31-34, Turkish.
  • Vancouver/ICMJE Style
    Şule Namlı, Abdullah Özkök, Yaşar Çolak, Nilgün Erten, M. Akif Karan, Cemil Taşçıoğlu, Abdülkadir Kaysı. [L-TİROKSİN YERİNE YANLIŞLIKLA UZUN SÜRE METOTREKSAT KULLANIMINA BAĞLI TOKSİSİTE: HASTALARI TEDAVİLERİ KONUSUNDA YETERİNCE BİLGİLENDİRİYOR MUYUZ?]. Nobel Med (2007); 3(3): 31-34, [cited Mayıs 24, 2021], Turkish.
  • Harvard Style
    Şule Namlı, Abdullah Özkök, Yaşar Çolak, Nilgün Erten, M. Akif Karan, Cemil Taşçıoğlu, Abdülkadir Kaysı. (2007) [L-TİROKSİN YERİNE YANLIŞLIKLA UZUN SÜRE METOTREKSAT KULLANIMINA BAĞLI TOKSİSİTE: HASTALARI TEDAVİLERİ KONUSUNDA YETERİNCE BİLGİLENDİRİYOR MUYUZ?]. Nobel Med, 3(3): 31-34, Turkish.