Objective: Although the relationship between ABO blood phenotype and atherosclerosis has been investigated; to our knowledge, new atherogenic indices, including the atherogenic index (AI), atherogenic plasma index (AIP), lipoprotein combined index (LCI), and Castelli's risk indices, have not been extensively discussed. The aim of this study is to investigate the effects of new atherogenic indices in determining atherogenic risk in men who appear healthy according to ABO blood phenotypes.

Material and Method: The study included 188 apparently healthy male medical staff (≥18 years); the participants were grouped according to their ABO blood group phenotype (A, B, AB, O or non-O blood). Laboratory tests included assessment of ABO blood types and measurements of the levels of total cholesterol (TC), high- and low-density lipoprotein cholesterol (HDL–C and LDL–C), and triglycerides (TGs). Also novel atherogenic risk indices were calculated.

Results: Although smoking was significantly higher in the AB blood phenotype group among the study groups, there was no significant difference in terms of TC, TGs, LDL-C and HDL-C levels. However, the new atherogenic risk indices AI, AIP, LCI and non-HDL, TG/HDL-C values were significantly higher in AB blood group phenotype (p<0.05 for each).

Conclusion: The statistically significant relationship between AB blood phenotype and new atherogenic indices (AI, AIP, LCI and TG/HDL-C ratio) found in this study supports the potential role of new atherogenic risk indices in the pathogenesis of atherosclerosis .

ABO phenotypes Atherosclerosis Atherogenic indices Cholesterol