REVIEW
Nobel Med 2021; 17(1): 5-11

PERIPHERAL N-METHYLASPARTATE RECEPTORS IN CARDIOVASCULAR DISEASES AND DIABETES MELLITUS

Zinnet Şevval Aksoyalp, Cahit Nacitarhan
ABSTRACT
Glutamate is the dominant excitatory amino acid mediator in the central nervous system and its receptors are divided into metabotropic and ionotropic receptors. N-methylaspartate (NMDA) receptors are a member of the ionotropic glutamate receptor family and these receptors are transmembrane ion channels with 7 different subunits. Depending on their subunit components and signal proteins NMDA receptors play a role in long- term potentiation or depression, stimulation or inhibition of neurotransmitter release, and cell survival or death. NMDA receptors are predominantly expressed in neurons. Recently, it has been shown that NMDA receptors are expressed in non-neuronal cells and peripheral tissues in the central nervous system and the distribution of these receptors outside the central nervous system has emerged as an interesting topic. Recent findings suggest that NMDA receptors may be present in multiple cells and tissues including pancreatic islet cells, heart, lung, medulla, kidneys. Non-neuronal NMDA receptors play an important role in proliferation, apoptosis, cell adhesion and migration, actin rearrangement, cell growth and differentiation, and regulation of hormone secretion and non-neuronal NMDA receptors may be involved in wound healing, insulin secretion, blood-brain barrier integrity, and myelination. In this review, the role of the NMDA receptors in the heart and pancreas is discussed and the therapeutic potential of these receptors in cardiovascular and diabetic diseases has been evaluated. New treatment options for chronic diseases can be provided by further investigation of non-neuronal NMDA receptors.

PERIPHERAL N-METHYLASPARTATE RECEPTORS IN CARDIOVASCULAR DISEASES AND DIABETES MELLITUS

05-11

Zinnet Şevval Aksoyalp, Cahit Nacitarhan

REVIEW Nobel Med 2021; 17(1): 5-11

EXAMINATION OF THE AFFECTING FACTORS FOR THE STATE OF CAUSES OF DEATH STATEMENTS WRITTEN IN DEATH CERTIFICATES: NIĞDE STUDY

12-19

Muhammet Bayraktar, Elçin Balcı

RESEARCH ARTICLE Nobel Med 2021; 17(1): 12-19

KNOWLEDGE, ATTITUDE AND APPROACHES OF INTENSIVE CARE NURSES ON ORGAN/TISSUE TRANSPLANTATION AND DONATION

20-29

Yeliz Şapulu Alakan, Faruk Aşıcıoğlu

RESEARCH ARTICLE Nobel Med 2021; 17(1): 20-29

THE PREVALENCE OF DISABILITY AMONG HEALTH CARE WORKERS AND ASSOCIATED PROBLEMS: A SAMPLE FROM TURKEY

30-38

Metin Pıçakçıefe, Volkan Akkaya, Erkan Erbaş

RESEARCH ARTICLE Nobel Med 2021; 17(1): 30-38

EVALUATION OF ANTIMICROBIAL SUSCEPTIBILITY AND CLONAL RELATIONSHIPS OF ACINETOBACTER BAUMANNII ISOLATES PRODUCED FROM PATIENTS IN A UNIVERSITY HOSPITAL

39-47

Seher Durukan, Cem Çelik, Ayşe Hümeyra Taşkın Kafa, Mürşit Hasbek

RESEARCH ARTICLE Nobel Med 2021; 17(1): 39-47

SERUM UROKINASE-TYPE PLASMINOGEN ACTIVATORRECEPTOR INPATIENTS WITH ACUTE PANCREATITIS

48-53

Ümmügülsüm Can, Salih Başer, Fatma Hümeyra Yerlikaya, Deniz Karasoy

RESEARCH ARTICLE Nobel Med 2021; 17(1): 48-53

THYROID VOLUME IN YOUNG MALES WITH IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM VERSUS YOUNG HEALTHY MALES

54-58

Ersen Karakılıç, Bercem Ayçiçek, Mazhar Müslüm Tuna, Mehtap Navdar Başaran, Mustafa Unal, Dilek Berker, Serdar Güler

RESEARCH ARTICLE Nobel Med 2021; 17(1): 54-58

RETROSPECTIVELY COMPARISON OF NASAL SEPTUM AND MAXILLARY SINUS RADIOLOGICAL FINDINGS IN CONE BEAM COMPUTED TOMOGRAPHY AND PANORAMIC RADIOGRAPHY

59-64

Numan Dedeoğlu, Büşra Arıkan, Şuayip Burak Duman

RESEARCH ARTICLE Nobel Med 2021; 17(1): 59-64

INCREASING THE NUMBER OF SELECTED HOSPITAL WARDS FOR MEDICAL INTERNS AS A USEFUL EDUCATIONAL METHOD IN IRANIAN MEDICAL SCHOOLS: A CASE STUDY OF AHVAZ JUNDISHAPUR UNIVERSITY

65-69

Ahmad Reza Mohtadi, Mahdi Bijanzadeh, Afsoon Bagheri

REPORT Nobel Med 2021; 17(1): 65-69

DR. BEHÇET UZ (1893-1986)

70-74

Zafer Öztek

A PORTRAIT Nobel Med 2021; 17(1): 70-74

LIVER AND SYSTEMIC DISEASES

05-09

Sebati Özdemir

REVIEW Nobel Med 2013; 9(2): 5-9

AGING KIDNEY: SENESCENCE OR DISEASE?

10-14

Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk

REVIEW Nobel Med 2013; 9(2): 10-14

IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS

15-20

Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş

RESEARCH ARTICLE Nobel Med 2013; 9(2): 15-20

EVALUATION OF PHYSICAL GROWTH IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER

21-25

Celalettin Koşan, Oğuzhan Sepetçigil, Atilla Çayır, Avni Kaya, Behzat Özkan

RESEARCH ARTICLE Nobel Med 2013; 9(2): 21-25

COMPARISON OF RISK INDEXES USED IN DETERMINING THE POSTOPERATIVE RESPIRATORY INSUFFICIENCY RISK

26-31

Gülsüm Kavalcı, Cavidan Arar, Alkın Çolak, Nesrin Turan, Cemil Kavalcı

RESEARCH ARTICLE Nobel Med 2013; 9(2): 26-31

THE EVALUATION OF PRENATAL AND ENVIROMENTAL RISK FACTORS IN CHILDREN WITH ASTHMA, ALLERGIC RHINITIS AND BRONCHIAL ASTHMA ABSTRACT

32-37

Mehmet İbrahim Turan, Müferet Ergüven, Mehmet Özdemir

RESEARCH ARTICLE Nobel Med 2013; 9(2): 32-37

REOPERATIONS AND MORBIDITY IN THYROID SURGERY

38-42

Serkan Teksöz, Murat Özcan, Aytül Sargan, Yusuf Bukey, Recep Özgültekin, Ateş Özyeğin

RESEARCH ARTICLE Nobel Med 2013; 9(2): 38-42

EFFECTS OF RAMADAN FASTING ON BLOOD PRESSURE CONTROL, LIPID PROFILE, BRAIN NATRIURETIC PEPTIDE, RENAL FUNCTIONS AND ELECTROLYTE LEVELS IN HYPERTENSIVE PATIENTS TAKING COMBINATION THERAPY

43-46

İbrahim Faruk Aktürk, İsmail Bıyık, Cüneyt Koşaş, Ahmet Arif Yalçın, Mehmet Ertürk, Fatih Uzun

RESEARCH ARTICLE Nobel Med 2013; 9(2): 43-46

MANAGEMENT OF A LARGE OUTBREAK CAUSED BY NOROVIRUS AND CAMPYLOBACTER JEJUNI OCCURRED IN A RURAL AREA IN TURKEY

47-51

İbak Gönen

RESEARCH ARTICLE Nobel Med 2013; 9(2): 47-51

FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES

52-56

Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu

RESEARCH ARTICLE Nobel Med 2013; 9(2): 52-56
  • Pubmed Style
    Zinnet Şevval Aksoyalp, Cahit Nacitarhan. [KARDİYOVASKÜLER HASTALIKLAR VE DİABETES MELLİTUSTA PERİFERAL N-METİL-D-ASPARTAT RESEPTÖRLERİ]. Nobel Med 2021; 17(1): 5-11, Turkish.
  • Web Style
    Zinnet Şevval Aksoyalp, Cahit Nacitarhan. [KARDİYOVASKÜLER HASTALIKLAR VE DİABETES MELLİTUSTA PERİFERAL N-METİL-D-ASPARTAT RESEPTÖRLERİ]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish.
  • AMA (American Medical Association) Style
    Zinnet Şevval Aksoyalp, Cahit Nacitarhan. [KARDİYOVASKÜLER HASTALIKLAR VE DİABETES MELLİTUSTA PERİFERAL N-METİL-D-ASPARTAT RESEPTÖRLERİ]. Nobel Med 2021; 17(1): 5-11, Turkish.
  • Vancouver/ICMJE Style
    Zinnet Şevval Aksoyalp, Cahit Nacitarhan. [KARDİYOVASKÜLER HASTALIKLAR VE DİABETES MELLİTUSTA PERİFERAL N-METİL-D-ASPARTAT RESEPTÖRLERİ]. Nobel Med (2021); 17(1): 5-11, [cited Mayıs 24, 2021], Turkish.
  • Harvard Style
    Zinnet Şevval Aksoyalp, Cahit Nacitarhan. (2021) [KARDİYOVASKÜLER HASTALIKLAR VE DİABETES MELLİTUSTA PERİFERAL N-METİL-D-ASPARTAT RESEPTÖRLERİ]. Nobel Med, 17(1): 5-11, Turkish.