REPORT
Nobel Med 2017; 13(3): 66-68

LEFLUNOMIDE AND CIDOFOVIR FOR THE TREATMENT OF BK VIRUS NEPHROPATHY

Sara Yavuz, Mehmet Tuncay, Erkan Dervişoğlu, Kürşat Yıldız, Betül Kalender Gönüllü, Süheyla Güven Apaydın
ABSTRACT
BK virus–associated nephropathy has become increasingly recognized cause of graft dysfunction among kidney transplant recipients and a definitive diagnosis requires a renal biopsy. While reducing the dose of immunosupressants is considered to be the standard therapy, adjunct agents (e.g., cidofovir) may be warranted. In the present case, BK nephropathy was suspected due to a progressive rise in serum creatinine. The blood and urine were tested for the presence of BK virus via polymerase chain reaction (PCR). Moreover, viruria without viremia

was confirmed, following which a gradual reduction in the dose of immunosuppressive therapy was applied. Due to the failure of viral clearance and a steady increase in the serum creatinine levels, leflunomide was added to the treatment; however, effective viral clearance could not be obtained. Cidofovir treatment was then added to the leflunomide therapy, and this combined regimen provided effective viral clearance in the urine. Renal graft function was preserved for as long as eight weeks of treatment.
Keywords
BK polyomavirus Nephropathy Cidofovir Leflunomide

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  • Pubmed Style
    Sara Yavuz, Mehmet Tuncay, Erkan Dervişoğlu, Kürşat Yıldız, Betül Kalender Gönüllü, Süheyla Güven Apaydın. [LEFLUNOMIDE AND CIDOFOVIR FOR THE TREATMENT OF BK VIRUS NEPHROPATHY]. Nobel Med 2017; 13(3): 66-68, English.
  • Web Style
    Sara Yavuz, Mehmet Tuncay, Erkan Dervişoğlu, Kürşat Yıldız, Betül Kalender Gönüllü, Süheyla Güven Apaydın. [LEFLUNOMIDE AND CIDOFOVIR FOR THE TREATMENT OF BK VIRUS NEPHROPATHY]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English.
  • AMA (American Medical Association) Style
    Sara Yavuz, Mehmet Tuncay, Erkan Dervişoğlu, Kürşat Yıldız, Betül Kalender Gönüllü, Süheyla Güven Apaydın. [LEFLUNOMIDE AND CIDOFOVIR FOR THE TREATMENT OF BK VIRUS NEPHROPATHY]. Nobel Med 2017; 13(3): 66-68, English.
  • Vancouver/ICMJE Style
    Sara Yavuz, Mehmet Tuncay, Erkan Dervişoğlu, Kürşat Yıldız, Betül Kalender Gönüllü, Süheyla Güven Apaydın. [LEFLUNOMIDE AND CIDOFOVIR FOR THE TREATMENT OF BK VIRUS NEPHROPATHY]. Nobel Med (2017); 13(3): 66-68, [cited Mayıs 24, 2021], English.
  • Harvard Style
    Sara Yavuz, Mehmet Tuncay, Erkan Dervişoğlu, Kürşat Yıldız, Betül Kalender Gönüllü, Süheyla Güven Apaydın. (2017) [LEFLUNOMIDE AND CIDOFOVIR FOR THE TREATMENT OF BK VIRUS NEPHROPATHY]. Nobel Med, 13(3): 66-68, English.