RESEARCH ARTICLE
Nobel Med 2005; 1(3): 04-06

EFFECTS OF PEG-INTERFERON + RIBAVIRIN COMBINATION TREATMENT ON THE GLUCOSE METABOLISM IN THE PATIENTS WITH CHRONIC HEPATITIS C

Ahmet Uludağ, Müjdat Canöz, Aylin İzat, Cüneyt Müderrisoğlu, Habip Gedik, Nurettin Tunç
ABSTRACT
Aims: Diabetes mellitus (DM) is common in patients with chronic hepatitis C. The aim of this study is to show the effects of interferon (IFN) on glucose metabolism in patients with chronic hepatitis C.
Material and methods: We performed oral glucose tolerance test (OGTT) in 45 chronic hepatitis C patients (20 male, 25 female) diagnosed by serologic and histologic data.

Results: Body mass index (BMI) and 75 g OGTT was performed to all patients before IFN therapy. Patients with impaired OGTT were not included in the study. Combination therapy of Peg-IFN and ribavirin were used and OGTT was performed after one year of the therapy. Glucose intolerance was found in 16 of the patients (35%); 7 of them were diabetic while 9 had impaired glucose tolerance.

Conclusions: We suggest to examine fasting glucose level and OGTT before and after the IFN therapy.
Keywords
Hepatitis Intetferon O rai glucose tölerance test

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  • Pubmed Style
    Ahmet Uludağ, Müjdat Canöz, Aylin İzat, Cüneyt Müderrisoğlu, Habip Gedik, Nurettin Tunç. [KRONİK HEPATİT C HASTALARINDA PEG-İNTERFERON+RİBAVİRİN KOMBİNASYON TEDAVİSİNİN GLUKOZ METABOLİZMASINA ETKİLERİ]. Nobel Med 2005; 1(3): 04-06, Turkish.
  • Web Style
    Ahmet Uludağ, Müjdat Canöz, Aylin İzat, Cüneyt Müderrisoğlu, Habip Gedik, Nurettin Tunç. [KRONİK HEPATİT C HASTALARINDA PEG-İNTERFERON+RİBAVİRİN KOMBİNASYON TEDAVİSİNİN GLUKOZ METABOLİZMASINA ETKİLERİ]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish.
  • AMA (American Medical Association) Style
    Ahmet Uludağ, Müjdat Canöz, Aylin İzat, Cüneyt Müderrisoğlu, Habip Gedik, Nurettin Tunç. [KRONİK HEPATİT C HASTALARINDA PEG-İNTERFERON+RİBAVİRİN KOMBİNASYON TEDAVİSİNİN GLUKOZ METABOLİZMASINA ETKİLERİ]. Nobel Med 2005; 1(3): 04-06, Turkish.
  • Vancouver/ICMJE Style
    Ahmet Uludağ, Müjdat Canöz, Aylin İzat, Cüneyt Müderrisoğlu, Habip Gedik, Nurettin Tunç. [KRONİK HEPATİT C HASTALARINDA PEG-İNTERFERON+RİBAVİRİN KOMBİNASYON TEDAVİSİNİN GLUKOZ METABOLİZMASINA ETKİLERİ]. Nobel Med (2005); 1(3): 04-06, [cited Mayıs 24, 2021], Turkish.
  • Harvard Style
    Ahmet Uludağ, Müjdat Canöz, Aylin İzat, Cüneyt Müderrisoğlu, Habip Gedik, Nurettin Tunç. (2005) [KRONİK HEPATİT C HASTALARINDA PEG-İNTERFERON+RİBAVİRİN KOMBİNASYON TEDAVİSİNİN GLUKOZ METABOLİZMASINA ETKİLERİ]. Nobel Med, 1(3): 04-06, Turkish.