INVESTIGATION OF THE SUSCEPTIBILITY OF EXTENDED SPECTRUM BETA-LACTAMASE (ESBL) PRODUCING ESCHERICHIA COLI AND KLEBSIELLA SPP. STRAINS TO COMBINATIONS OF CARBAPENEMS AND BETA-LACTAMASE INHIBITORS
Kutbettin Demirdağ, Pınar Yüce, Mehmet Özden, Ahmet KalkanABSTRACT
Material and Method: A total of 300 strain, 230 E. coli, 43 K. pneumoniae and 27 K. oxytoca collected from the inpatients with nosocomial infections admitted to our Institute. ESBL production of the strains were determined by using Double-disk synergy (DDS) test. The susceptibility of the strains against to the studied antibiotics was investigated with broth microdulition method according to the recommendations of NCCLS.
Results: No resistance to imipenem and meropenem among E. coli and Klebsiella spp was detected. Susceptibility of E. coli strains to piperacillin-tazobactam, cefoperazone-sulbactam and amoxicillin-clavulanic acid was found as 75.2%, 72.6% and 29.3, respectively. Piperacillin-tazobactam and cephoperazon-sulbactam were determined as equally active as 69.8% to K. pneumoniae strains. Susceptibility of K. oxytoca strains to piperacillin-tazobactam and cephoperazon-sulbactam was found as 55.8% and 40.7%, orderly. The susceptibility of amoxicillin-clavulanic acid among K. pneumoniae and K. oxytoca strains was detected as 23.3% and 18%, respectively.
Conclusion: Piperacillin-tazobactam was found relatively more active against ESBL producing E. coli and K. oxytoca strains, than the cefoperazone-sulbactam. Since both antibiotics were found equally sensitive in K. pneumoniae strains they may be used in life-threatening infections when susceptible.
IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL PRESENTATION OF APOPTOSIS AND AQUEOUS HUMOR’S NITRIC OXIDE LEVELS IN KERATOCONUS
05-09Emre Uzunoğlu, Neşe Lortlar, Deniz Erdoğan, Hüsamettin Erdamar, Ece Şahin Akyol, Fikret Akata
RESEARCH ARTICLE Nobel Med 2013; 9(1): 05-09THE ANALYSIS OF UNIT COST OF ADULT ANGIOGRAPHY SERVICES IN A STATE HOSPITAL BY ACTIVITY-BASED COST METHOD
10-16Halise Uğurtay, Figen Öker, Haydar Sur, İhsan Bakır, M. Şemsettin Döğücü
RESEARCH ARTICLE Nobel Med 2013; 9(1): 10-16CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR GENE MUTATIONS IN PATIENTS WITH MASSIVE NASAL POLYPOSIS
17-20Yusuf Kızıl, Mehmet Ali Ergün, Utku Aydil, Sabri Uslu
RESEARCH ARTICLE Nobel Med 2013; 9(1): 17-20COMPARISON OF THE EFFICACY OF LORNOXICAM, MEPERIDINE AND MORPHINE WITH PATIENT CONTROLLED ANALGESIA METHOD AFTER LUMBAR DISK HERNIA SURGERY
21-26Zeki Tuncel Tekgül, Avni Babacan
RESEARCH ARTICLE Nobel Med 2013; 9(1): 21-26THE EFFECTS OF NOVEL STIMULI ON P3B POTANTIAL IN AUDITORY THREE-STIMULUS PARADIGM ABSTRACT
27-33Tolgay Ergenoğlu, Fazilet Ertürk, Figen Dağ, Berrin Maraşlıgil, Mehmet Ali Sungur
RESEARCH ARTICLE Nobel Med 2013; 9(1): 27-33THE EFFECT OF GASTRIC INFLAMMATION AND HELICOBACTER PYLORI INFECTION ON LIVER HISTOLOGY IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION
34-41Bahadır Ceylan, Hasan Bektaş, Gülhan Eren, Muzaffer Fincancı, Cüneyt Müderrisoğlu, Esra Paşaoğlu, Erol Rüştü Bozkurt
RESEARCH ARTICLE Nobel Med 2013; 9(1): 34-41HISTOCHEMICAL RESEARCH OF NITRIC OXIDE SYNTETAHASE AND RENIN GRANULES IN ALBINO MOUSE (BALB/ C) KIDNEY
42-48Hatice Yorulmaz, Cihan Demirci
RESEARCH ARTICLE Nobel Med 2013; 9(1): 42-48CLINICAL EVALUATION OF CHILDRENS WITH SUBACUTE SCLEROSING PANENCEPHALITIS
49-55Suat Biçer, Ömer Faruk Beşer, Gülseren Arslan, Ender Aksüyek, Canan Kocaman, Erdal Adal, Rengin Şiraneci
RESEARCH ARTICLE Nobel Med 2013; 9(1): 49-55URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE LEVELS IN CANCER PATIENTS TREATED WITH CISPLATIN
56-60Hakan Sakallı, Züleyha Çalıkuşu, Barış Sarıakçalı, Ayşe Polat, Abdullah Canataroğlu
RESEARCH ARTICLE Nobel Med 2013; 9(1): 56-60SUICIDAL IDEATIONS AND ATTEMPTS IN PATIENTS ADMITTED TO PSYCHIATRY OUTPATIENT CLINIC
61-66Demet Güleç Öyekçin, Erkan Melih Şahin
RESEARCH ARTICLE Nobel Med 2013; 9(1): 61-66EFFICIACY OF NEBULIZED IPRATROPIUM BROMIDE IN THE TREATMENT OF ACUTE ASTHMA IN CHILDREN: RANDOMISED, DOUBLE BLIND, PLACEBO-CONTROLLED TRIAL
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76-80Cihan Ünlü, Gürkan Erdoğan, Fuat Torun, Ece Turan Vural, Tülin Bozkurt Balta, Hüseyin Bayramlar
RESEARCH ARTICLE Nobel Med 2013; 9(1): 76-80THE EFFECTS OF ANTIDEPRESSANT DRUGS ON POLYMORPHONUCLEAR LEUKOCYTE FUNCTIONS AND LEVELS OF FOLIC ACID, VITAMIN B12, ZINC AND COPPER IN MAJOR DEPRESSION
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RESEARCH ARTICLE Nobel Med 2013; 9(1): 81-88INVESTIGATION OF THE SUSCEPTIBILITY OF EXTENDED SPECTRUM BETA-LACTAMASE (ESBL) PRODUCING ESCHERICHIA COLI AND KLEBSIELLA SPP. STRAINS TO COMBINATIONS OF CARBAPENEMS AND BETA-LACTAMASE INHIBITORS
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100-105Aybala Ağaç Ay, Suat Kutun, Haluk Ulucanlar, Ahmet Ay, Oğuz Tarcan, Abdullah Demir, Abdullah Çetin
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106-109Ayhan Akbulut, Özlem Çağaşar, Mehmet Özden, Hatice Handan Akbulut, Kudbettin Demirdağ
RESEARCH ARTICLE Nobel Med 2013; 9(1): 106-109TYPE 1 CROUZON SYNDROME WITH HEADACHE
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113-114Levend Özkan, Cüneyd Özkürkçügil, Kürşat Yıldız
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124-126Çağatay Üstün
A PORTRAIT Nobel Med 2013; 9(1): 124-126LIVER AND SYSTEMIC DISEASES
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32-37Mehmet İbrahim Turan, Müferet Ergüven, Mehmet Özdemir
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47-51İbak Gönen
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RESEARCH ARTICLE Nobel Med 2013; 9(2): 52-56-
Pubmed Style
Kutbettin Demirdağ, Pınar Yüce, Mehmet Özden, Ahmet Kalkan. [INVESTIGATION OF THE SUSCEPTIBILITY OF EXTENDED SPECTRUM BETA-LACTAMASE (ESBL) PRODUCING ESCHERICHIA COLI AND KLEBSIELLA SPP. STRAINS TO COMBINATIONS OF CARBAPENEMS AND BETA-LACTAMASE INHIBITORS]. Nobel Med 2013; 9(1): 89-94, English. -
Web Style
Kutbettin Demirdağ, Pınar Yüce, Mehmet Özden, Ahmet Kalkan. [INVESTIGATION OF THE SUSCEPTIBILITY OF EXTENDED SPECTRUM BETA-LACTAMASE (ESBL) PRODUCING ESCHERICHIA COLI AND KLEBSIELLA SPP. STRAINS TO COMBINATIONS OF CARBAPENEMS AND BETA-LACTAMASE INHIBITORS]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English. -
AMA (American Medical Association) Style
Kutbettin Demirdağ, Pınar Yüce, Mehmet Özden, Ahmet Kalkan. [INVESTIGATION OF THE SUSCEPTIBILITY OF EXTENDED SPECTRUM BETA-LACTAMASE (ESBL) PRODUCING ESCHERICHIA COLI AND KLEBSIELLA SPP. STRAINS TO COMBINATIONS OF CARBAPENEMS AND BETA-LACTAMASE INHIBITORS]. Nobel Med 2013; 9(1): 89-94, English. -
Vancouver/ICMJE Style
Kutbettin Demirdağ, Pınar Yüce, Mehmet Özden, Ahmet Kalkan. [INVESTIGATION OF THE SUSCEPTIBILITY OF EXTENDED SPECTRUM BETA-LACTAMASE (ESBL) PRODUCING ESCHERICHIA COLI AND KLEBSIELLA SPP. STRAINS TO COMBINATIONS OF CARBAPENEMS AND BETA-LACTAMASE INHIBITORS]. Nobel Med (2013); 9(1): 89-94, [cited Mayıs 24, 2021], English. -
Harvard Style
Kutbettin Demirdağ, Pınar Yüce, Mehmet Özden, Ahmet Kalkan. (2013) [INVESTIGATION OF THE SUSCEPTIBILITY OF EXTENDED SPECTRUM BETA-LACTAMASE (ESBL) PRODUCING ESCHERICHIA COLI AND KLEBSIELLA SPP. STRAINS TO COMBINATIONS OF CARBAPENEMS AND BETA-LACTAMASE INHIBITORS]. Nobel Med, 9(1): 89-94, English.