RESEARCH ARTICLE
Nobel Med 2012; 8(3): 108-112
DEMONSTRATION OF BARTONELLA HENSELAE-INDUCED ANGIOGENESIS USING CHORIOALLANTOIC MEMBRANE ASSAY ON SHELL-LESS CULTURE OF THE CHICK EMBRYO AS IN VIVO MODEL
Çağrı Ergin, A. Çevik Tufan, Cansev YılmazABSTRACT
Material and Method: Eight shell-less CAM cultures were established 72 hours after first incubation of fertilized eggs at 37oC and 5% CO2. One half of each CAM was used as the study group and in this half 3 B.henselae (ATCC 49882) soaked beads were planted in bifurcations of previously established vessels. The other half was used as a control, and sterile distilled water soaked beads were planted in bifurcations of previously established vessels. Beads were removed after 40 and 62 hours of incubation, and newly formed vessels were counted in a 4-mm2 area under each bead.
Results: Neovascularization in the study group was significantly higher than that in control group (22.8±1.4 versus 8.3±0.7, respectively; p<0.001) at 40 hours of incubation. This significance was also observed at 62 hours of incubation (25.6±1.8 versus 9.4±0.9, respectively; p<0.001).
Conclusion: Bartonella henselae induced angiogenesis has been demonstrated in shell-less culture of CAM. This model has advantages for angiogenesis studies. These include: (a) cost efficiency (eggs, time, labor, etc.); (b) no mature immune system is available in these CAMs, thus the observed effect is attributed to the bacteria tested; (c) allowing multiple tests on individual CAMs; (d) easy reproduciblity; (e) tissue sampling and photography is easily performed. Thus, shell-less culture of the CAM may be utilized in studies testing angiogenic activity of many agents including other bacteria.
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Pubmed Style
Çağrı Ergin, A. Çevik Tufan, Cansev Yılmaz. [BARTONELLA HENSELAE TARAFINDAN UYARILAN ANJİOGENEZİN, İN VİVO MODEL OLARAK YUMURTA AÇIĞINDA, KABUKSUZ TAVUK EMBRİYOSU KÜLTÜRÜ ÜZERİNDE, KORYOALLANTOİK MEMBRANDA GÖSTERİLMESİ]. Nobel Med 2012; 8(3): 108-112, Turkish. -
Web Style
Çağrı Ergin, A. Çevik Tufan, Cansev Yılmaz. [BARTONELLA HENSELAE TARAFINDAN UYARILAN ANJİOGENEZİN, İN VİVO MODEL OLARAK YUMURTA AÇIĞINDA, KABUKSUZ TAVUK EMBRİYOSU KÜLTÜRÜ ÜZERİNDE, KORYOALLANTOİK MEMBRANDA GÖSTERİLMESİ]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish. -
AMA (American Medical Association) Style
Çağrı Ergin, A. Çevik Tufan, Cansev Yılmaz. [BARTONELLA HENSELAE TARAFINDAN UYARILAN ANJİOGENEZİN, İN VİVO MODEL OLARAK YUMURTA AÇIĞINDA, KABUKSUZ TAVUK EMBRİYOSU KÜLTÜRÜ ÜZERİNDE, KORYOALLANTOİK MEMBRANDA GÖSTERİLMESİ]. Nobel Med 2012; 8(3): 108-112, Turkish. -
Vancouver/ICMJE Style
Çağrı Ergin, A. Çevik Tufan, Cansev Yılmaz. [BARTONELLA HENSELAE TARAFINDAN UYARILAN ANJİOGENEZİN, İN VİVO MODEL OLARAK YUMURTA AÇIĞINDA, KABUKSUZ TAVUK EMBRİYOSU KÜLTÜRÜ ÜZERİNDE, KORYOALLANTOİK MEMBRANDA GÖSTERİLMESİ]. Nobel Med (2012); 8(3): 108-112, [cited Mayıs 24, 2021], Turkish. -
Harvard Style
Çağrı Ergin, A. Çevik Tufan, Cansev Yılmaz. (2012) [BARTONELLA HENSELAE TARAFINDAN UYARILAN ANJİOGENEZİN, İN VİVO MODEL OLARAK YUMURTA AÇIĞINDA, KABUKSUZ TAVUK EMBRİYOSU KÜLTÜRÜ ÜZERİNDE, KORYOALLANTOİK MEMBRANDA GÖSTERİLMESİ]. Nobel Med, 8(3): 108-112, Turkish.