THE ROLE OF PROCALCITONIN, C-REACTIVE PROTEIN, INTERLEUKIN-6, INTERLEUKIN-8 AND ENDOTOXIN IN THE EARLY DIAGNOSIS AND FOLLOW-UP OF LOCAL INFECTIONS
Şua Sümer, İbrahim Erayman, Emel Türk ArıbaşABSTRACT
Material and Method: A total of 67 patients (33/34 patients with urinary tract and wound infections) between May 2006-June 2007 at various departments and intensive care units of Selçuk University Meram Medical School Hospital were evaluated. The control group consisted of 20 healthy individuals. The patients over the age of 18, with no history of antibiotic therapy were included in the urinary tract infection group if they were symptomatic and had a positive urine test.
The patients who were monitored with the diagnosis of decubitus / diabetic foot ulcers or surgical zone infection who had positive wound culture tests were included in the wound infection group. The patients with negative culture results were excluded regardless of data indicating infection.
Results: In the wound infection group changes of PCT, CRP, IL-6, IL-8 and endotoxin levels were from baseline to day 7 respectively 0.12/4.74–0.05/0.94 ng/ml, 11.3/203–4.17/200 mg/dl, 2.70/22.79–1.07/10.25 pg/ml, 0.19/5–0.1/4.8 pg/ml, 0.01/6.25–0.01/0.86 pg/ml (p?0.001). In the urinary tract infection group changes of CRP, IL-6, IL-8 and endotoxin levels were detected from baseline to day 7 respectively 3.17/200–2.1/126 mg/dl, 1.26/14.25–0.8/6.85 pg/ml, 0.49/4.6–0.07/3.2 pg/ml, 0.07/9.65–0.01/3.65 pg/ml (p?0.001). Changes in PCT level was statistically significant in the wound infection group (p?0.001) but was not statistically significant in the urinary tract infection group (p=0.004).
Conclusion: PCT, CRP and endotoxin levels are useful tools for clinicians to differantiate local infections from the healthy people. CRP, IL-6, IL-8 and endotoxin levels are useful tools for follow-up urinary tract and wound infections.
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Pubmed Style
Şua Sümer, İbrahim Erayman, Emel Türk Arıbaş . [THE ROLE OF PROCALCITONIN, C-REACTIVE PROTEIN, INTERLEUKIN-6, INTERLEUKIN-8 AND ENDOTOXIN IN THE EARLY DIAGNOSIS AND FOLLOW-UP OF LOCAL INFECTIONS]. Nobel Med 2012; 8(1): 61-66, English. -
Web Style
Şua Sümer, İbrahim Erayman, Emel Türk Arıbaş . [THE ROLE OF PROCALCITONIN, C-REACTIVE PROTEIN, INTERLEUKIN-6, INTERLEUKIN-8 AND ENDOTOXIN IN THE EARLY DIAGNOSIS AND FOLLOW-UP OF LOCAL INFECTIONS]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English. -
AMA (American Medical Association) Style
Şua Sümer, İbrahim Erayman, Emel Türk Arıbaş . [THE ROLE OF PROCALCITONIN, C-REACTIVE PROTEIN, INTERLEUKIN-6, INTERLEUKIN-8 AND ENDOTOXIN IN THE EARLY DIAGNOSIS AND FOLLOW-UP OF LOCAL INFECTIONS]. Nobel Med 2012; 8(1): 61-66, English. -
Vancouver/ICMJE Style
Şua Sümer, İbrahim Erayman, Emel Türk Arıbaş . [THE ROLE OF PROCALCITONIN, C-REACTIVE PROTEIN, INTERLEUKIN-6, INTERLEUKIN-8 AND ENDOTOXIN IN THE EARLY DIAGNOSIS AND FOLLOW-UP OF LOCAL INFECTIONS]. Nobel Med (2012); 8(1): 61-66, [cited Mayıs 24, 2021], English. -
Harvard Style
Şua Sümer, İbrahim Erayman, Emel Türk Arıbaş . (2012) [THE ROLE OF PROCALCITONIN, C-REACTIVE PROTEIN, INTERLEUKIN-6, INTERLEUKIN-8 AND ENDOTOXIN IN THE EARLY DIAGNOSIS AND FOLLOW-UP OF LOCAL INFECTIONS]. Nobel Med, 8(1): 61-66, English.