BACTERIAL SPECTRUM AND ANTIMICROBIAL SUSCEPTIBILITY PROFILE IN BLOOD CULTURES OF PATIENTS WITH FEBRILE NEUTROPENIA

RESEARCH ARTICLE

Nobel Med 2011; 7(1): 74-78

BACTERIAL SPECTRUM AND ANTIMICROBIAL SUSCEPTIBILITY PROFILE IN BLOOD CULTURES OF PATIENTS WITH FEBRILE NEUTROPENIA

Süreyya Gül Yurtsever, Nihan Çeken, Bahriye Payzın, Nükhet Kurultay, Füsun Topçugil, Mustafa Demirci

ABSTRACT

Objective: Empirical antimicrobial therapy is usually started in febrile neutropenic patients without having culture results. There is close relation between inapropriate initial antimicrobial therapy and mortality rate due to infections in these patients. The aim of this study was to help to determine the policies of empirical antibiotic usage in febrile neutropenic patients by detecting the antimicrobial susceptibility profile in this group of patients.

Material and Method: In this study, blood cultures taken from neutropenic patients hospitalized at the Departments of Hematology at Izmir Ataturk Research and Treatment Hospital between January 1, 2008 and December 31, 2008 were retrospectively evaluated. Positive blood cultures were entered in the study, if the bacteria were isolated from the BACTEC (Becton Dickinson, USA) blood culture systems. 196 pathogens accepted as pathogen were identified by conventional methods. The conventionaly unidentified species were identified by Phoneix TM 100 (Becton Dickinson, USA). Antimicrobial susceptibilities were determined by disc diffusion method according to the criteria of Clinical Laboratory Standarts Institute.

Results: Of 196 isolates analyzed, 101 (51%) were Gram positive cocci, 80 (41%) were Gram negative bacilli and 15 (8%) were fungi. Among Gram positive cocci 40% of the coagulase negative staphylococci isolates and (17%) of the Staphylococcus aureus isolates were resistant to oxacillin. Most frequently isolated Gram negative bacteria were Escherichia coli trimethoprim-sulfamethoxazole (84%), ciprofloxacin (76%) were the most resistant antimicrobial agents in E.coli species.

Other resistance rate were cefepime (41%), piperacillin-tazobactam (30%), imipenem (21%), respectively.

Conclusion: It was apparent that species resistant to carbapenems show an increasing tendence and these species are hospital originated multiple resistant Gram negative bacteria in this study.

Keywords

Febrile neutropenia Blood culture Antimicrobial susceptibility

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Pubmed Style
Süreyya Gül Yurtsever, Nihan Çeken, Bahriye Payzın, Nükhet Kurultay, Füsun Topçugil, Mustafa Demirci. [FEBRİL NÖTROPENİK HASTALARIN KAN KÜLTÜRLERİNDEN İZOLE EDİLEN MİKROORGANİZMALAR VE ANTİMİKROBİYAL DUYARLILIK PROFİLİ]. Nobel Med 2011; 7(1): 74-78, Turkish.
Web Style
Süreyya Gül Yurtsever, Nihan Çeken, Bahriye Payzın, Nükhet Kurultay, Füsun Topçugil, Mustafa Demirci. [FEBRİL NÖTROPENİK HASTALARIN KAN KÜLTÜRLERİNDEN İZOLE EDİLEN MİKROORGANİZMALAR VE ANTİMİKROBİYAL DUYARLILIK PROFİLİ]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish.
AMA (American Medical Association) Style
Süreyya Gül Yurtsever, Nihan Çeken, Bahriye Payzın, Nükhet Kurultay, Füsun Topçugil, Mustafa Demirci. [FEBRİL NÖTROPENİK HASTALARIN KAN KÜLTÜRLERİNDEN İZOLE EDİLEN MİKROORGANİZMALAR VE ANTİMİKROBİYAL DUYARLILIK PROFİLİ]. Nobel Med 2011; 7(1): 74-78, Turkish.
Vancouver/ICMJE Style
Süreyya Gül Yurtsever, Nihan Çeken, Bahriye Payzın, Nükhet Kurultay, Füsun Topçugil, Mustafa Demirci. [FEBRİL NÖTROPENİK HASTALARIN KAN KÜLTÜRLERİNDEN İZOLE EDİLEN MİKROORGANİZMALAR VE ANTİMİKROBİYAL DUYARLILIK PROFİLİ]. Nobel Med (2011); 7(1): 74-78, [cited Mayıs 24, 2021], Turkish.
Harvard Style
Süreyya Gül Yurtsever, Nihan Çeken, Bahriye Payzın, Nükhet Kurultay, Füsun Topçugil, Mustafa Demirci. (2011) [FEBRİL NÖTROPENİK HASTALARIN KAN KÜLTÜRLERİNDEN İZOLE EDİLEN MİKROORGANİZMALAR VE ANTİMİKROBİYAL DUYARLILIK PROFİLİ]. Nobel Med, 7(1): 74-78, Turkish.