CAN WE DETERMINE AN OPTIMUM CUT-OFF VALUE FOR CA-125 IN DIFFERENTIATION OF ADNEXIAL TUMORS?
A. Ender Yumru, Murat Bozkurt, Ebru İnci CoşkunABSTRACT
In patients with epithelial ovarian cancer, increased or decreased CA-125 levels have correlation with the activity of the disease in more than 90% of the patients. For differential diagnosis between benign and malign ovarian tumors and also for determination of the prognosis of the adnexial tumors, defining an ideal cut-off value is the objective of this research.
Material and Method: We examined the sensitivity, specificity, positive predictive and negative predictive value of CA-125 in patients with benign and malign ovarian tumors. In this retrospective study we took 168 patients whose CA-125 levels are known. Histopathologically malign lesions were detected in 30 patients, and benign lesions in 138 patients. CA-125 < 35 U/ml is accepted as normal level. Using numeric logistic system, we tried to find an ideal cut-off value for CA-125 to differentiate between benign and malign lesions.
Results: In malign ovarian cancers the average value of CA-125 was 183.344 (minimum 7.76, maximum value is 1032). The sensitivity of CA-125 in malign ovarian tumors, was 78.94%, specifity was 86.92%, positive predictive value was 63.82% and negative predictive value was 93.38%.
Conclusion: For differentiation of adnexial mass as benign or malign, CA-125 is found to be significant. But the sensitivity and specificity changed according to the estimated cut-off value of CA-125. When the cut-off value taken as 35 U/ml, then only 30 out of 38 cases could be labeled as malign. If the cut-off value is 65 U/ml, 25 of 38 malign cases are determined. The increase in specificity determines 124 benign cases instead of 113. If the cut-off is 35 U/ml, CA-125 gives one negative result for every 6 positive results.
TREATMENT OF BENIGN JOINT HYPERMOBILITY SYNDROME
05-08Bengü Beydağ Odabaşı, Yasemin Turan, Ömer Faruk Şendur
REVIEW Nobel Med 2010; 6(2): 05-08DISCHARGE PATTERNS OF THE SPASM ACTIVITY IN HEMIFACIAL SPASM: A SUMMARY OF 206 PATIENTS
09-14Meral Erdemir Kızıltan, Rahşan Şahin, Mehmet Ali Akalın, Nurten Uzun, Feray Karaali Savrun,
RESEARCH ARTICLE Nobel Med 2010; 6(2): 09-14THE EFFECT OF MATERNAL SMOKING ON ANTHROPOMETRIC MEASUREMENTS OF NEWBORNS
15-19Berrin Telatar, Ayça Vitrinel, Serdar Cömert, Ethem Erginöz, Engin Tutkun, Yasemin Akın
RESEARCH ARTICLE Nobel Med 2010; 6(2): 15-19AGE OF MENARCHE AND AFFECTING FACTORS IN FATIH DISTRICT OF ISTANBUL CITY
20-24Nurver Turfaner, Selçuk Köksal, Fahri Öçer, Fikret Sipahioğlu, Ayşe Kaypmaz
RESEARCH ARTICLE Nobel Med 2010; 6(2): 20-24EFFECTS OF COUNSELING ON SOME CARE OUTCOMES AMONG PATIENTS WITH BRAIN TUMOUR: PAIN, SEIZURE, CONSTIPATION, INFECTION, DISPATCH CONDITIONS
25-31Arzu Tuna Malak, Alev Dıramalı, Kemal Yücesoy
RESEARCH ARTICLE Nobel Med 2010; 6(2): 25-31A POSSIBLE DELETERIOUS EFFECT OF INCREASED SERUM COPPER ON MYOCARDIAL FUNCTION IN PATIENTS WITH DILATED CARDIOMYOPATHY AWAITING TRANSPLANTATION
32-36Kıvanç Çefle, Erol Erçağ, Serpil Gezertaş, Ayşem Uzer, Şükrü Öztürk, Ayşe Çefle, Şükrü Palandüz, Kerim Güler
RESEARCH ARTICLE Nobel Med 2010; 6(2): 32-36PLASMA D-DIMER LEVELS IN ACUTE ISCHEMIC STROKE: ASSOCIATION WITH MORTALITY, STROKE TYPE AND PROGNOSIS
37-42Mehmet Üstündağ, Murat Orak, Cahfer Güloğlu, Yusuf Tamam, Mustafa Burak Sayhan
RESEARCH ARTICLE Nobel Med 2010; 6(2): 37-42SERUM HS-CRP LEVELS DO NOT INDICATE THE SEVERITY OF LIVER DAMAGE IN NON-ALCOHOLIC STEATOHEPATITIS PATIENTS WITH TYPE-2 DIABETES MELLITUS
43-46Gönenç Kocabay, Aysegül Telci, Yıldız Tütüncü, Betül Tiryaki, Sevda Özel, Uğur Çevikbaş, Atilla Ökten, İlhan Satman
RESEARCH ARTICLE Nobel Med 2010; 6(2): 43-46EFFICACY OF DEXKETOPROFEN TROMETAMOL FOR ACUTE POSTOPERATIVE PAIN RELIEF AFTER ENT SURGERY: A COMPARISON WITH PARACETAMOL AND METAMIZOL
47-52Yücel Karaman, İbrahim Çukurova, Erhan Demirhan, Mustafa Gönüllü, Sermin Altunbaş
RESEARCH ARTICLE Nobel Med 2010; 6(2): 47-52A COMPARISON OF A RAPID UREASE TEST AND HISTOLOGY FOR THE DIAGNOSIS OF HELICOBACTER PYLORI INFECTION
53-56Mehmet Polat, Muhammed Saçıkara, Yaşar Nazlıgül, Naim Ata, Güler Kızılca, Heyecan Ökten
RESEARCH ARTICLE Nobel Med 2010; 6(2): 53-56NILOTINIB EFFICACY IN 21 IMATINIB-RESISTANT OR-INTOLERANT T (9;22) POSITIVE CHRONIC MYELOID LEUKEMIA PATIENTS WITH AND WITHOUT ADDITIONAL CHROMOSOMAL CHANGES
57-62Akif Selim Yavuz, Ömer Celal Elçioğlu, Timur Akpınar, Fulya Coşan, Ali Uçur, Ayşegül Bayrak, Kıvanç Çefle, Şükrü Öztürk, Şükrü Palanduz, Mustafa Nuri Yenerel, Melih Aktan, Meliha Nalçacı
RESEARCH ARTICLE Nobel Med 2010; 6(2): 57-62EVALUATION OF LANGERHANS CELLS COUNTS IN HEALTHY AND INFLAMMATORY SKIN DISEASE CASES
63-67Ece Şahin Akyol, Neşe Lortlar, Suna Ömeroğlu, Pınar Öztaş, M. Tahir Hatiboğlu
RESEARCH ARTICLE Nobel Med 2010; 6(2): 63-67PLASMA D-DIMER LEVELS IN ACUTE ISCHEMIC STROKE: ASSOCIATION WITH MORTALITY, STROKE TYPE AND PROGNOSIS
68-74Habip Gedik, Mehmet Yahyaoğlu, Muzaffer Fincancı
RESEARCH ARTICLE Nobel Med 2010; 6(2): 68-74CAN WE DETERMINE AN OPTIMUM CUT-OFF VALUE FOR CA-125 IN DIFFERENTIATION OF ADNEXIAL TUMORS?
75-78A. Ender Yumru, Murat Bozkurt, Ebru İnci Coşkun
RESEARCH ARTICLE Nobel Med 2010; 6(2): 75-78URINARY CALCIUM EXCRETION IN CITY OF VAN IN HEALTHY CHILDREN
79-84Cihangir Akgün, Ertan Sal, Necip Akgül, Avni Kaya, Sinan Akbayram, Mehmet Açıkgöz, Şükrü Arslan
RESEARCH ARTICLE Nobel Med 2010; 6(2): 79-84FUNCTIONAL BLINDNESS: BLEPHAROSPASM
85-89Gülden Avcı
REPORT Nobel Med 2010; 6(2): 85-89CONGENITAL HYPOTHYROIDISM WITH ISOLATED FIBULA AGENESIS
90-92Murat Doğan, Cahide Yılmaz, Hüseyin Çaksen, Yaşar Cesur, Fuat Akpınar, Ahmet Sami Güven
REPORT Nobel Med 2010; 6(2): 90-92NASOPHARYNGEAL CARCINOMA IN THE ETIOLOGY OF FEVER OF UNKNOWN ORIGIN
93-96Mehmet Uluğ, Mustafa Kemal Çelen, Mehmet Faruk Geyik, Recep Tekin, Celal Ayaz
REPORT Nobel Med 2010; 6(2): 93-96REVERSIBLE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME
97-100Mesut Okur, Cahide Yılmaz, Avni Kaya, Ahmet Sami Güven, Murat Doğan, Hüseyin Çaksen
REPORT Nobel Med 2010; 6(2): 97-100EMPHYSEMATOUS PYELONEPHRITIS CAUSED BY KLEBSIELLA OXYTOCA IN A PATIENT WITH DIABETIC NEPHROPATHY
101-104Cemal Bes, Kerem Okutur, Selçuk Şeber, Fatma Paksoy, Fatih Borlu
REPORT Nobel Med 2010; 6(2): 101-104RADIOLOGY IN TURKEY AND EMIN FAIK ÜSTÜN PROF. MD
105-108Çağatay Üstün
A PORTRAIT Nobel Med 2010; 6(2): 105-108LIVER AND SYSTEMIC DISEASES
05-09Sebati Özdemir
REVIEW Nobel Med 2013; 9(2): 5-9AGING KIDNEY: SENESCENCE OR DISEASE?
10-14Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk
REVIEW Nobel Med 2013; 9(2): 10-14IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS
15-20Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş
RESEARCH ARTICLE Nobel Med 2013; 9(2): 15-20EVALUATION OF PHYSICAL GROWTH IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER
21-25Celalettin Koşan, Oğuzhan Sepetçigil, Atilla Çayır, Avni Kaya, Behzat Özkan
RESEARCH ARTICLE Nobel Med 2013; 9(2): 21-25COMPARISON OF RISK INDEXES USED IN DETERMINING THE POSTOPERATIVE RESPIRATORY INSUFFICIENCY RISK
26-31Gülsüm Kavalcı, Cavidan Arar, Alkın Çolak, Nesrin Turan, Cemil Kavalcı
RESEARCH ARTICLE Nobel Med 2013; 9(2): 26-31THE EVALUATION OF PRENATAL AND ENVIROMENTAL RISK FACTORS IN CHILDREN WITH ASTHMA, ALLERGIC RHINITIS AND BRONCHIAL ASTHMA ABSTRACT
32-37Mehmet İbrahim Turan, Müferet Ergüven, Mehmet Özdemir
RESEARCH ARTICLE Nobel Med 2013; 9(2): 32-37REOPERATIONS AND MORBIDITY IN THYROID SURGERY
38-42Serkan Teksöz, Murat Özcan, Aytül Sargan, Yusuf Bukey, Recep Özgültekin, Ateş Özyeğin
RESEARCH ARTICLE Nobel Med 2013; 9(2): 38-42EFFECTS OF RAMADAN FASTING ON BLOOD PRESSURE CONTROL, LIPID PROFILE, BRAIN NATRIURETIC PEPTIDE, RENAL FUNCTIONS AND ELECTROLYTE LEVELS IN HYPERTENSIVE PATIENTS TAKING COMBINATION THERAPY
43-46İbrahim Faruk Aktürk, İsmail Bıyık, Cüneyt Koşaş, Ahmet Arif Yalçın, Mehmet Ertürk, Fatih Uzun
RESEARCH ARTICLE Nobel Med 2013; 9(2): 43-46MANAGEMENT OF A LARGE OUTBREAK CAUSED BY NOROVIRUS AND CAMPYLOBACTER JEJUNI OCCURRED IN A RURAL AREA IN TURKEY
47-51İbak Gönen
RESEARCH ARTICLE Nobel Med 2013; 9(2): 47-51FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES
52-56Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu
RESEARCH ARTICLE Nobel Med 2013; 9(2): 52-56-
Pubmed Style
A. Ender Yumru, Murat Bozkurt, Ebru İnci Coşkun . [CAN WE DETERMINE AN OPTIMUM CUT-OFF VALUE FOR CA-125 IN DIFFERENTIATION OF ADNEXIAL TUMORS?]. Nobel Med 2010; 6(2): 75-78, English. -
Web Style
A. Ender Yumru, Murat Bozkurt, Ebru İnci Coşkun . [CAN WE DETERMINE AN OPTIMUM CUT-OFF VALUE FOR CA-125 IN DIFFERENTIATION OF ADNEXIAL TUMORS?]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English. -
AMA (American Medical Association) Style
A. Ender Yumru, Murat Bozkurt, Ebru İnci Coşkun . [CAN WE DETERMINE AN OPTIMUM CUT-OFF VALUE FOR CA-125 IN DIFFERENTIATION OF ADNEXIAL TUMORS?]. Nobel Med 2010; 6(2): 75-78, English. -
Vancouver/ICMJE Style
A. Ender Yumru, Murat Bozkurt, Ebru İnci Coşkun . [CAN WE DETERMINE AN OPTIMUM CUT-OFF VALUE FOR CA-125 IN DIFFERENTIATION OF ADNEXIAL TUMORS?]. Nobel Med (2010); 6(2): 75-78, [cited Mayıs 24, 2021], English. -
Harvard Style
A. Ender Yumru, Murat Bozkurt, Ebru İnci Coşkun . (2010) [CAN WE DETERMINE AN OPTIMUM CUT-OFF VALUE FOR CA-125 IN DIFFERENTIATION OF ADNEXIAL TUMORS?]. Nobel Med, 6(2): 75-78, English.