RESEARCH ARTICLE
Nobel Med 2010; 6(1): 56-60
LAMIVUDINE RESISTANCE AND THE FACTORS AFFECTING IT IN CHRONIC HEPATITIS B PATIENTS
Muharrem Doğan, Cüneyt Müderrisoğlu, Muzaffer Fincancı, Bahadır Ceylan, Gülhan Eren Özdemir, Hayri PolatABSTRACT
Aim of this study, to investigate lamivudine resistance ratio and the factors affecting in the resistance in chronic hepatitis B patients treated in our clinic between January 2003 and December 2007.
Material and Method: All the chronic hepatitis B patients who used lamivudine for the first time were included in this study. The treatment responses and YMDD mutation analysis were studied in the 3rd, 6th, 9th, 12th, 15th, 18th, 24th, 30th, 36th, 42nd and 48th months of the treatment.
Baseline parameters of patients who developed lamivudine resistance were compared with those who did not develop resistance.
Results: We tried to find out whether there was a correlation between; gender, body mass index, ALT and HBV-DNA levels and also HBeAg seropositivity before treatment, age of the patient, combination and monotheraphy, duration of the treatment, alcohol abuse and smoking during the treatment and lamivudine resistance.
Conclusion: Our results indicated correlation between lamivudine resistance and duration of the treatment (p=0,04), and also HBeAg seropositivity (p=0,0001).
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Pubmed Style
Muharrem Doğan, Cüneyt Müderrisoğlu, Muzaffer Fincancı, Bahadır Ceylan, Gülhan Eren Özdemir, Hayri Polat. [KRONİK HEPATİT B'DE LAMİVUDİN DİRENCİ VE LAMİVUDİN DİRENCİ GELİŞİMİ ÜZERİNE ETKİLİ FAKTÖRLER]. Nobel Med 2010; 6(1): 56-60, Turkish. -
Web Style
Muharrem Doğan, Cüneyt Müderrisoğlu, Muzaffer Fincancı, Bahadır Ceylan, Gülhan Eren Özdemir, Hayri Polat. [KRONİK HEPATİT B'DE LAMİVUDİN DİRENCİ VE LAMİVUDİN DİRENCİ GELİŞİMİ ÜZERİNE ETKİLİ FAKTÖRLER]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish. -
AMA (American Medical Association) Style
Muharrem Doğan, Cüneyt Müderrisoğlu, Muzaffer Fincancı, Bahadır Ceylan, Gülhan Eren Özdemir, Hayri Polat. [KRONİK HEPATİT B'DE LAMİVUDİN DİRENCİ VE LAMİVUDİN DİRENCİ GELİŞİMİ ÜZERİNE ETKİLİ FAKTÖRLER]. Nobel Med 2010; 6(1): 56-60, Turkish. -
Vancouver/ICMJE Style
Muharrem Doğan, Cüneyt Müderrisoğlu, Muzaffer Fincancı, Bahadır Ceylan, Gülhan Eren Özdemir, Hayri Polat. [KRONİK HEPATİT B'DE LAMİVUDİN DİRENCİ VE LAMİVUDİN DİRENCİ GELİŞİMİ ÜZERİNE ETKİLİ FAKTÖRLER]. Nobel Med (2010); 6(1): 56-60, [cited Mayıs 24, 2021], Turkish. -
Harvard Style
Muharrem Doğan, Cüneyt Müderrisoğlu, Muzaffer Fincancı, Bahadır Ceylan, Gülhan Eren Özdemir, Hayri Polat. (2010) [KRONİK HEPATİT B'DE LAMİVUDİN DİRENCİ VE LAMİVUDİN DİRENCİ GELİŞİMİ ÜZERİNE ETKİLİ FAKTÖRLER]. Nobel Med, 6(1): 56-60, Turkish.