RESEARCH ARTICLE
Nobel Med 2009; 5(2): 29-34

EVENT-RELATED POTENTIALS AND PASAT EVALUATION IN BEHÇET’S SYNDROME WITH SUBCLINICAL NEURAL INVOLVEMENT

Gökhan Erkol, Melih Vural, Fatma Karantay, Derya Uluduz, Mehmet Ali Akalın, Meral E. Kızıltan
ABSTRACT
Objective
Behçet’s Syndrome (BS), an inflammatory disorder, may affect central nervous system. A subclinical involvement, mainly affecting cognitive functions, might be observed in patients with BS. The aim of this study was to investigate this subclinical involvement.

Material and Method
Event-related potentials (P300) and Paced Auditory Serial Addition Test (PASAT) were used. Patients with BS with normal MRI (BS), patients with neuro-BS and healthy subjects were enrolled to this study. Both BS and neuro-BS patients consisted of 14 patients (8 men and 6 women, mean age 35.9±8.2; 9 men and 5 women, mean age 36.7±8.3 respectively). There were 12 healthy subjects (8 men and 4women, mean age 32.2±5.3) in control group.

Results
P300 latencies obtained from central and frontal region were significantly longer for BS (p=0.006, p=0.039) and neuro-BS (p=0.019, p=0.026) groups compared to controls. The latency on parietal region was significantly longer in BS group (p=0.03), but not in neuro-BS group (p=0.081). Concerning the amplitude, values obtained in parietal region in both BS (p=0.008) and neuro-BS groups (p=0.033) and obtained from frontal region for BS group (p=0.044) were significantly lower than control group.
According to PASAT results, controls performed better when compared both to BS and neuro-BS groups.

Conclusion
BS group displayed similar electrophysiological changes and PASAT results compared to controls. Therefore our results suggested that P300 and PASAT might be used as objective methods in detecting subtle involvement that may be due to impairment of large scale attention-executive function-working memory network in patients with BS without overt neurological involvement.
Keywords
Behçet’s disease PASAT Event-related potentials Clinical neurophysiology

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  • Pubmed Style
    Gökhan Erkol, Melih Vural, Fatma Karantay, Derya Uluduz, Mehmet Ali Akalın, Meral E. Kızıltan. [EVENT-RELATED POTENTIALS AND PASAT EVALUATION IN BEHÇET’S SYNDROME WITH SUBCLINICAL NEURAL INVOLVEMENT]. Nobel Med 2009; 5(2): 29-34, English.
  • Web Style
    Gökhan Erkol, Melih Vural, Fatma Karantay, Derya Uluduz, Mehmet Ali Akalın, Meral E. Kızıltan. [EVENT-RELATED POTENTIALS AND PASAT EVALUATION IN BEHÇET’S SYNDROME WITH SUBCLINICAL NEURAL INVOLVEMENT]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English.
  • AMA (American Medical Association) Style
    Gökhan Erkol, Melih Vural, Fatma Karantay, Derya Uluduz, Mehmet Ali Akalın, Meral E. Kızıltan. [EVENT-RELATED POTENTIALS AND PASAT EVALUATION IN BEHÇET’S SYNDROME WITH SUBCLINICAL NEURAL INVOLVEMENT]. Nobel Med 2009; 5(2): 29-34, English.
  • Vancouver/ICMJE Style
    Gökhan Erkol, Melih Vural, Fatma Karantay, Derya Uluduz, Mehmet Ali Akalın, Meral E. Kızıltan. [EVENT-RELATED POTENTIALS AND PASAT EVALUATION IN BEHÇET’S SYNDROME WITH SUBCLINICAL NEURAL INVOLVEMENT]. Nobel Med (2009); 5(2): 29-34, [cited Mayıs 24, 2021], English.
  • Harvard Style
    Gökhan Erkol, Melih Vural, Fatma Karantay, Derya Uluduz, Mehmet Ali Akalın, Meral E. Kızıltan. (2009) [EVENT-RELATED POTENTIALS AND PASAT EVALUATION IN BEHÇET’S SYNDROME WITH SUBCLINICAL NEURAL INVOLVEMENT]. Nobel Med, 5(2): 29-34, English.