RESEARCH ARTICLE
Nobel Med 2008; 4(3): 15-19

THE RELATION OF ORLISTAT AND GREEN TEA WITH ß-CATENIN AND PROLIFERATION ON GASTROINTESTINAL EPITHELIAL CELLS

Elif İlkay Taşkın, Kadriye Akgün Dar, Ayşegül Kapucu, Korhan Altunbaş, İbrahim Fırat, Hüsniye Doğruman
ABSTRACT
Purpose: To investigate the relation of gastrointestinal effects of Orlistat and green tea with ß-catenin and proliferation immunohistochemically.
Material ve Method: In our study, 40 female Wistar albino rats were divided into 4 groups as control, Orlistat, green tea extract, Orlistat+green tea extract. Orlistat (10 mg/kg/day), green tea extract (40mg/kg/day) via gavage were applied for a duration of 1 month. At the end of the duration, colons of all animals were removed and inbedded in parafin following routine histological procedures. ß-catenin and Ki-67 were applied to the obtained sections and the results were scored.
Findings: Proliferation and H-score results were significantly higher in Orlistat and Orlistat+green tea extract-applied groups than control or green tea extract-applied groups (p<0.001). No difference was observed in green tea extract applied group when compared with control group.
Result: In this study, we suggest that orlistat stimulates proliferation. However, green tea has no effect on the reversal of proliferation.
Keywords
Orlistat Beta-catenin Colon Green tea Rat

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  • Pubmed Style
    Elif İlkay Taşkın, Kadriye Akgün Dar, Ayşegül Kapucu, Korhan Altunbaş, İbrahim Fırat, Hüsniye Doğruman. [SIÇAN KOLON EPİTELİ PROLİFERASYONUNA ORLİSTAT VE YEŞİL ÇAYIN ETKİSİ, BETA-KATENİN İLE OLAN İLİŞKİSİ]. Nobel Med 2008; 4(3): 15-19, Turkish.
  • Web Style
    Elif İlkay Taşkın, Kadriye Akgün Dar, Ayşegül Kapucu, Korhan Altunbaş, İbrahim Fırat, Hüsniye Doğruman. [SIÇAN KOLON EPİTELİ PROLİFERASYONUNA ORLİSTAT VE YEŞİL ÇAYIN ETKİSİ, BETA-KATENİN İLE OLAN İLİŞKİSİ]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish.
  • AMA (American Medical Association) Style
    Elif İlkay Taşkın, Kadriye Akgün Dar, Ayşegül Kapucu, Korhan Altunbaş, İbrahim Fırat, Hüsniye Doğruman. [SIÇAN KOLON EPİTELİ PROLİFERASYONUNA ORLİSTAT VE YEŞİL ÇAYIN ETKİSİ, BETA-KATENİN İLE OLAN İLİŞKİSİ]. Nobel Med 2008; 4(3): 15-19, Turkish.
  • Vancouver/ICMJE Style
    Elif İlkay Taşkın, Kadriye Akgün Dar, Ayşegül Kapucu, Korhan Altunbaş, İbrahim Fırat, Hüsniye Doğruman. [SIÇAN KOLON EPİTELİ PROLİFERASYONUNA ORLİSTAT VE YEŞİL ÇAYIN ETKİSİ, BETA-KATENİN İLE OLAN İLİŞKİSİ]. Nobel Med (2008); 4(3): 15-19, [cited Mayıs 24, 2021], Turkish.
  • Harvard Style
    Elif İlkay Taşkın, Kadriye Akgün Dar, Ayşegül Kapucu, Korhan Altunbaş, İbrahim Fırat, Hüsniye Doğruman. (2008) [SIÇAN KOLON EPİTELİ PROLİFERASYONUNA ORLİSTAT VE YEŞİL ÇAYIN ETKİSİ, BETA-KATENİN İLE OLAN İLİŞKİSİ]. Nobel Med, 4(3): 15-19, Turkish.